FCI in Post-operative Low Grade Gliomas

NCT06294418 | Completed

• 1 other identifier: 1-037-23
• Study Type: interventional
• Target: 9
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this pilot study is to explore the utility of a new imaging technique, called Field Cycling Imaging (FCI), in postoperative low grade gliomas. The main question it aims to answer is if FCI can differentiate subtypes of low grade gliomas. Participants will have one FCI scan.

Conditions

Glioma

Outcome Measures

Primary Outcomes (1)

• Differentiation of sub-types of low grade glioma assessed by Field Cycling Imaging (FCI) T1 dispersion profiles

  Validation of FCI T1 dispersion profiles as a non-invasive technology to differentiate sub-types of low grade glioma.

  At baseline

Study Arms (1)

Low grade glioma

EXPERIMENTAL

Patients with postoperative low grade glioma will undergo one FCI scan.

Device: Field Cycling Imaging (FCI)

Interventions

Field Cycling Imaging (FCI) DEVICE

FCI scan

Low grade glioma

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with post operative low-grade glioma.
• Capacity to give informed consent.
• Capacity to co-operate with the scanning procedures and duration.
• Age 16 and above.
• Participants who can pass through a 50 cm-diameter circular hoop to ensure they will be able to fit inside the scanner.
• Participants who meet the safety criteria for undergoing an MRI scan.
• Participants must be mobile enough to be positioned onto the FCI scanner couch.

You may not qualify if:

• MRI-incompatible conditions, as detected in the MRI safety screening form.
• Restrictions to mobility that would prevent the correct positioning in the scanner by trained research radiographer (e.g., severe kyphosis).
• Participants who are unable to give fully informed consent.
• Women who are pregnant.
• Participants who are unable to understand or communicate in English.
• Patients who suffer from claustrophobia.

Sponsors & Collaborators

• NHS Grampian: lead
• University of Aberdeen: collaborator

Study Sites (1)

Aberdeen Royal Infirmary

Aberdeen, AB25 2ZD, United Kingdom

Location

MeSH Terms

Conditions

Glioma

Condition Hierarchy (Ancestors)

Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue

Study Officials

• Arnab K Rana, Dr

  University of Aberdeen

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 26, 2024
• First Posted: March 5, 2024
• Study Start: February 15, 2024
• Primary Completion: March 31, 2026
• Study Completion: March 31, 2026
• Last Updated: April 20, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)