tACS Treatment for Cognitive Impairments in Methamphetamine Addicts

NCT06292156 | Completed DMC

• 1 other identifier: CASPsy7
• Study Type: interventional
• Target: 68
• Locations: 1 country
• Sites: 1

Brief Summary

1. 1.To evaluate the cognitive function of methamphetamine Patients.
2. 2.Investigate the pathological mechanism of methamphetamine patients from the aspects of EEG and biology;
3. 3.The investigators investigated the effects of transcranial alternating current stimulation (tACS) on cognitive impairments in methamphetamine patients

Conditions

Methamphetamine Abuse

Keywords

Methamphetamine patients; Cognitive impairments; tACS

Outcome Measures

Primary Outcomes (11)

• The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)

  The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), which contains 12 subtests for calculating the index scores of delayed memory (including list recall, story recall, figure recall, and list recognition tests), attention (including digit span and coding tests), language (including picture naming and semantic fluency tests), visuospatial/constructional index (including figure copy and line orientation tasks), immediate memory (including list learning and story memory tasks), and global neuropsychological function.

  Baseline, week 3

• ERP components associated with cognitive function

  Investigate the ERP components associated with cognitive function of methamphetamine patients using event-related potential analysis

  Baseline, week 3

• Condition stop signal task

  Condition stop signal task was used to assess cognitive control function, including proactive control and reactive control.

  Baseline, week 3

• Neural oscillations associated with cognitive function

  Investigate the neural oscillations associated with cognitive function of methamphetamine patients using time-frequency analysis.

  Baseline, week 3

• Functional connection of brain region associated with cognitive function

  Investigate the functional connection of brain region associated with cognitive function of methamphetamine patients using functional connection analysis

  Baseline, week 3

• Microstate associated with cognitive function

  Investigate the microstate associated with cognitive function of methamphetamine patients using microstate analysis

  Baseline, week 3

• Neural Dynamic Coding of brain region associated with cognitive function

  Investigate the functional connection of brain region associated with cognitive function of methamphetamine patients using multivariate pattern analysis

  baseline, week 3

• The effect of oxidative stress system on cognitive function

  The investigators examined markers of oxidative stress related to cognitive function using bioassay.

  Baseline, week 3

• The effect of immune system on cognitive function

  The investigators immune indicators related to cognitive function using bioassay.

  Baseline, week 3

• The effect of brain derived neurotrophic factor(BDNF) on cognitive function

  The investigators BDNF indicators related to cognitive function using bioassay.

  Baseline, week 3

• Genetic mechanism of cognitive function

  The investigators performed comprehensive genetic testing to explore the genetic mechanism of cognitive function.

  Baseline, week 3

Secondary Outcomes (16)

• Reverse learning task

  Baseline, week 3

• Beck Depression Scale

  Baseline, week 3

• Barrett impulse Scale

  Baseline, week 3

• Degree of insomnia

  Baseline, week 3

• The Sensitivity to Punishment and Reward Questionnaire

  Baseline, week 3

Study Arms (2)

Theta treatment group

EXPERIMENTAL

In active tACS, the target 'active' electrode was placed over the MFC and the second 'return' electrode was placed over the medial parietal cortex. 6 Hz stimulation was used and a alternating current of 2mA was applied for 30min each day(Monday-Friday) for 3 consecutive weeks.

Device: Theta treatment group

Sham control group

SHAM COMPARATOR

In sham group, Sham stimulation lasted 30 s (15 s of ramp- up and 15 of ramp-down) .

Device: Sham control group

Interventions

Theta treatment group DEVICE

The target 'active' electrode was placed over the MFC and the second 'return' electrode was placed over the medial parietal cortex. 6 Hz stimulation was used and a alternating current of 2mA was applied for 30min each day(Monday-Friday) for 3consecutive weeks

Theta treatment group

Sham control group DEVICE

Sham stimulation lasted 30 s (15 s of ramp- up and 15 s of ramp-down).

Sham control group

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Clinical diagnosis diagnosis of methamphetamine use disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)
• None of participants had mixed use of other drugs
• None of participants had physical disability
• None of participants had acute physical or mental illness, hallucinations, acute withdrawal symptoms
• None of participants were receiving any medical treatment

You may not qualify if:

• Intracranial hypertension
• Cranial defects
• Tumors
• Serious physical illnesses (e.g., cardiovascular, liver, kidney, gastrointestinal disorders)
• Infectious diseases
• Immune system disorders

Sponsors & Collaborators

• Beijing HuiLongGuan Hospital: lead

Study Sites (1)

Xin Hua Drug Rehabilitation Center

Mianyang, China

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 3, 2023
• First Posted: March 4, 2024
• Study Start: December 30, 2023
• Primary Completion: December 30, 2024
• Study Completion: December 30, 2024
• Last Updated: December 19, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)