Peer Engagement in Methamphetamine Harm-Reduction With Contingency Management (PEER-CM)

NCT05700994 | Active Not Recruiting

• 1 other identifier: PEER-CM
• Study Type: interventional
• Target: 1,283
• Locations: 1 country
• Sites: 2

Brief Summary

The main goal of this study is to tests the effect of incentivizing achievement of self-identified, personal harm reduction goals (Contingency management or CM) compared with standard of care (peer harm reduction service with incentives for peer visits) to increase the reach and effectiveness of methamphetamine (MA) harm reduction services.

Conditions

Methamphetamine Abuse

Outcome Measures

Primary Outcomes (3)

• Number of participants who overdose

  Test the impact of incentives for achieving self-identified, personal harm reduction goals on the likelihood of overdose among people using methamphetamine at 6 months from enrollment identified through completed assessment.

  6 months from baseline

• Number of participants who achieve self-identified goals

  Determine whether incentives for achieving self-identified, personal harm reduction goals increases engagement with harm reduction services at 6 months from enrollment identified through completed assessment.

  6 months from baseline

• Number of participants who engage in substance use disorder treatment

  Determine whether incentives for achieving self-identified, personal harm reduction goals increases engagement with treatment services at 6 months from enrollment identified through completed assessment.

  6 months from baseline

Study Arms (2)

PEER-CM

EXPERIMENTAL

Peer-facilitated contingency management (PEER-CM).

Behavioral: Peer Contingency Management

Standard of Care

ACTIVE COMPARATOR

Standard of care contingency management.

Behavioral: Standard of Care Contingency Management

Interventions

Peer Contingency Management BEHAVIORAL

Participants allocated to peer-facilitated contingency management will receive incentives for achieving self-identified harm reduction goals set with peer specialists using a participant-driven harm reduction goal-setting process (e.g. completing overdose prevention and supply training, daily life goals, treatment and care goals, relationship and social support goals)

Also known as: PEER-CM

PEER-CM

Standard of Care Contingency Management BEHAVIORAL

Participants allocated to standard of care contingency management will receive incentives for peer encounters.

Also known as: Standard of Care

Standard of Care

Eligibility Criteria

• Age: 18 Years - 105 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• This intervention is at the site level. Community-based organization sites are eligible if they:
• Use peer support specialists to provide direct outreach and harm reduction services to people who use drugs
• Are willing to be trained in the two strategies for peer-facilitated contingency management
• Clients who:
• Age 18 and older
• Any stimulant (methamphetamine, cocaine) use in the past 30 days
• Willing to accept peer services
• Willing to complete initial and follow-up assessments with peer
• Able to communicate in English or Spanish

You may not qualify if:

• Community-based organization sites who:
• Do not use peer support specialists to provide direct outreach and harm reduction services to people who use drugs
• Are not willing to be trained in the two strategies for peer-facilitated contingency management
• Clients who:
• Present any danger or threat of violence to peers

Sponsors & Collaborators

• Oregon Health and Science University: lead
• Comagine Health: collaborator
• Oregon Health Authority: collaborator

Study Sites (2)

Comagine Health

Portland, Oregon, 97232, United States

Location

Oregon Health & Science University

Portland, Oregon, 97239, United States

Location

Related Publications (2)

• Cooke A, Stack E, Peng L, Cook R, Hartzler B, Leichtling G, Hildebran C, Leahy JM, Payne KS, Kunkel LE, Hoffman K, Korthuis PT. The peers expanding engagement in stimulant harm reduction with contingency management study: a protocol paper. Addict Sci Clin Pract. 2025 Jun 10;20(1):48. doi: 10.1186/s13722-025-00577-8.

  PMID: 40495203 DERIVED

• Peng L, Stack E, Cooke A, Hartzler B, Cook R, Leichtling G, Hildebran C, Leahy J, Payne KS, Kunkel L, Hoffman K, Korthuis PT. Centering peers in design and training for a peer-delivered contingency management program for self-identified harm reduction and treatment goals. Harm Reduct J. 2025 May 6;22(Suppl 1):72. doi: 10.1186/s12954-025-01213-z.

  PMID: 40329274 DERIVED

MeSH Terms

Interventions

Standard of Care

Intervention Hierarchy (Ancestors)

Quality Indicators, Health Care; Quality of Health Care; Health Services Administration; Health Care Quality, Access, and Evaluation

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: This is a cluster-randomized pragmatic trial using a hybrid type 1 effectiveness-implementation framework and stepped-wedge design.

Study Record Dates

• First Submitted: January 17, 2023
• First Posted: January 26, 2023
• Study Start: November 13, 2023
• Primary Completion (Estimated): September 30, 2026
• Study Completion (Estimated): September 30, 2026
• Last Updated: January 14, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (2)