Behçet and LDH/Albumin

NCT06276829 | Completed

• 1 other identifier: 02.05.2023/291
• Study Type: observational
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

ABSTRACT Objective: To investigate whether the lactate dehydrogenase to albumin ratio can be used as a parameter to determine disease severity in Behçet's disease, an inflammatory disease, by comparing it to healthy controls. Patients and Methods: In this retrospective cohort study, patients with Behçet's disease aged 18-69 years who presented to the outpatient clinic between February 2020 and April 2023 and healthy individuals of similar age and gender were enrolled. LDH, albumin levels, and LDH/albumin ratio of both groups were compared. Clinical findings and characteristics of Behçet's patients and disease severity were recorded and analyzed in relation to LDH/albumin ratio.

Conditions

Behcet's Disease; Albumin; Lactate Dehydrogenase; Disease Severity

Outcome Measures

Primary Outcomes (1)

• LDH/albumin ratio

  February 2020 and April 2023

Study Arms (2)

Behçet's Disease

Diagnostic Test: LDH/albumin ratio

healthy individuals

Diagnostic Test: LDH/albumin ratio

Interventions

LDH/albumin ratio DIAGNOSTIC_TEST

LDH/Albumin ratios of patient and control groups were recorded.

Behçet's Disease; healthy individuals

Eligibility Criteria

• Age: 18 Years - 69 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

A total of 349 subjects, including 160 patients with Behçet's disease and 189 healthy controls

You may qualify if:

• Patients with Behçet's disease aged 18-69

You may not qualify if:

• younger than 18 years or older than 69 years, pregnant and lactating patients, patients with acute infection on admission or nutritional problems, symptomatic gastrointestinal symptoms, malignancy, hepatitis or liver disease were excluded.

Sponsors & Collaborators

• Ataturk University: lead

Study Sites (1)

Erdal Pala

Erzurum, 25240, Turkey (Türkiye)

Location

Related Publications (1)

• Pala E, Bayraktar M. Lactate dehydrogenase to albumin ratio as a convenient parameter for predicting the severity of Behcet disease: a cross-sectional study. BMC Immunol. 2026 Jan 7;27(1):1. doi: 10.1186/s12865-025-00706-7.

  PMID: 41501648 DERIVED

MeSH Terms

Conditions

Behcet Syndrome

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Uveitis, Anterior; Panuveitis; Uveitis; Uveal Diseases; Eye Diseases; Vasculitis; Vascular Diseases; Cardiovascular Diseases; Hereditary Autoinflammatory Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin Diseases, Genetic; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Vascular

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 3 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Department of Skin and Venereal Diseases

Study Record Dates

• First Submitted: February 18, 2024
• First Posted: February 26, 2024
• Study Start: February 1, 2020
• Primary Completion: April 1, 2023
• Study Completion: April 1, 2023
• Last Updated: February 26, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)