Postoperative Pancreatic Fistula in Patients Undergoing Pancreaticoduodenectomy

NCT06300801 | Unknown

• 2 other identifiers: 2023-48hitit
• Study Type: expanded_access
• Target: N/A
• Locations: 1 country
• Sites: 2

Brief Summary

Pancreaticoduodenectomy (PD) is a complex procedure performed in patients with malignant or benign tumors of the pancreatic head and periampullary region, associated with high morbidity and mortality. Postoperative pancreatic fistula (POPF) is the most common and clinically significant complication following PD. In this study, the investigators aim to predict pancreatic fistula using the C-reactive protein-albumin ratio (CAR). The total number of participants expected to be included in this research comprises patients who underwent PD between 2017 and 2023 and developed pancreatic fistula. The participants invitation is based on the detection of a pancreatic fistula. This study is conducted for research purposes and participation is voluntary. No interventions will be performed on the participants as part of this study; however, we have prepared this form to obtain participant permission to gather certain information. If the participants consent to the use of information for scientific purposes with the guarantee of confidentiality, they will be asked to sign a consent form.

Conditions

Pancreatic Fistula After Pancreaticoduodenectomy; C-Reactive Protein; Albumin

Keywords

albumin; pancreatic fistula; c- reactive protein

Interventions

Is the preoperative c-reactive protein/albumin ratio successful in predicting postoperative pancreatic fistula in patients undergoing pancreatoduodenectomy? DIAGNOSTIC_TEST

In this study, predicting pancreatic fistula before surgery will reduce postoperative complications and mortality.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged between 18 and 80 years
• Diagnosed with pancreatic cancer
• Patients without recurrence

You may not qualify if:

• Patients who underwent total pancreatectomy
• Data were not available
• Patients outside the specified age range

Sponsors & Collaborators

• Erol Olcok Corum Training and Research Hospital: lead

Study Sites (2)

Hitit University Erol olçok Traning and research Hospital

Çorum, Merkez, 19000, Turkey (Türkiye)

Location

Hitit University Erol olçok Traning and resourge Hospital

Çorum, Merkez, 19000, Turkey (Türkiye)

Location

Related Publications (1)

• Sakamoto T, Yagyu Y, Uchinaka EI, Morimoto M, Hanaki T, Tokuyasu N, Honjo S, Fujiwara Y. Predictive Significance of C-reactive Protein-to-albumin Ratio for Postoperative Pancreatic Fistula After Pancreaticoduodenectomy. Anticancer Res. 2019 Nov;39(11):6283-6290. doi: 10.21873/anticanres.13838.

  PMID: 31704858 BACKGROUND

MeSH Terms

Conditions

Pancreatic Fistula

Condition Hierarchy (Ancestors)

Digestive System Fistula; Digestive System Diseases; Pancreatic Diseases; Fistula; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: expanded access
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 16, 2024
• First Posted: March 8, 2024
• Last Updated: March 8, 2024

Record last verified: 2024-02

Locations

TU (2)