Acute Effects of High-intensity Interval Training With Mindfulness-based Recovery on Executive Function in Children

NCT06270589 | Recruiting DMC

• 1 other identifier: IRB-2023-1684
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this randomized cross-over trial is to learn about the effect of a single bout of 20-min mindfulness-based high-intensity interval training (MF-HIIT), MF-only, and HIIT-only in relative to sitting rest on executive function (EF) in 10-12 years old children. The main question it aims to answer are: Question 1: Whether a single bout of 20-min MF-HIIT has larger beneficial effect on EF performance than that following a 20-min session of MF-only and HIIT-only in relative to the sitting rest Question 2: Whether a single bout of 20-min MF-HIIT has a larger beneficial effect on brain functioning, as measured by the N2 and P3 components of event-related potential (ER) during EF performance than that following a 20-min session of MF-only and HIIT-only in relative to the sitting rest Participants will visit the laboratory on 5 separate days (\> 2-day washout between days) in which they have not previously participated in structured physical activities. Participants will complete the testing and/or receive treatments below: Day 1:

• Kaufman Brief Intelligence Test (KBIT) to assess intelligence quotient
• Treadmill-based exercise test to measure cardiorespiratory fitness (maximum oxygen consumption) Days 2-5
• Each day, participants will complete each of the four intervention conditions (MF-HIIT, MF-only, HIIT-only, sitting)
• Participants' heart rate and self-reported affect and rating of physical exertion will be measured
• Participants will complete a modified flanker task and a task-switching task to assess inhibitory control and cognitive flexibility
• Participants will wear an EEG cap to measure the N2 and P3 components of the event-related potential during the inhibitory control and cognitive flexibility performance Researcher will compare the cognitive outcome measures following the MF-HIIT, MF-only, and HIIT-only conditions with the sitting condition to see if MF and HIIT has beneficial effects on children's EF. Further, researcher will compare the cognitive outcome measures following the MF-HIIT compared with MF-only and HIIT-only conditions to see if combining MF with HIIT has greater beneficial effects on children's EF than MF and HIIT alone.

Conditions

Healthy Volunteers

Keywords

Interval Exercise; Mindfulness; Executive function; Brain function; Children

Outcome Measures

Primary Outcomes (6)

• Inhibition speed

  Inhibition speed will be assessed by the response time (ms) during a child-friendly flanker task.

  At the baseline before and about 10-min after the 20-min intervention on Day 2, Day 3, Day 4, and Day 5.

• Inhibition accuracy

  Inhibition accuracy will be assessed by the response accuracy (%) during a child-friendly flanker task.

  At the baseline before and about 10-min after the 20-min intervention on Day 2, Day 3, Day 4, and Day 5.

• Shifting speed

  The shifting speed will be assessed by the response time (ms) during a child-friendly switching task.

  At the baseline before and about 10-min after the 20-min intervention on Day 2, Day 3, Day 4, and Day 5.

• Shifting accuracy

  The shifting accuracy will be assessed by the response accuracy (%) during a child-friendly switching task.

  At the baseline before and about 10-min after the 20-min intervention on Day 2, Day 3, Day 4, and Day 5.

• N2-ERP

  The N2 component of event-related brain potentials is a neuroelectric index of conflict processing. Increased amplitude of N2 reflects increased neural activation to detect and resolve conflicts.

  At the baseline before and about 10-min after the 20-min intervention on Day 2, Day 3, Day 4, and Day 5.

• P3-ERP

  The P3 component of event-related brain potentials is a neuroelectric index of attention. Increased amplitude of P3 reflects greater allocation of attentional resources and the decreased latency of P3 reflects the faster information processing speed.

  At the baseline before and about 10-min after the 20-min intervention on Day 2, Day 3, Day 4, and Day 5.

Secondary Outcomes (3)

• State Mindfulness Scale for Physical Activity (SMSPA)

  Immediately after completing the 20-min intervention on Day 2, Day 3, Day 4, and Day 5.

• Rating of perceived exertion

  Measure at 0 second, 90 seconds, 180 seconds, 270 seconds, 360 seconds, 450 seconds, 540 seconds, 630 seconds, 720 seconds, 810 seconds, 900 seconds, 990 seconds, 1080 seconds and 1200 seconds of the 20-min intervention on Day 2, Day 3, Day 4, and Day 5.

• Heart Rate

  Heart rate will be measured at every minute (minutes 0, 1, 2, 3, 4, ...., 18, 19, 20) during the 20-min intervention on Day 2, Day 3, Day 4, and Day 5.

Other Outcomes (1)

• Dispositional mindfulness

  At baseline on Day 1 before receiving any intervention

Study Arms (4)

A Single Bout Of Mindful High-Intensity Interval Training (Mindful HIIT)

EXPERIMENTAL

Behavioral: MF-HIIT

A Single Bout Of High-Intensity Interval Training (HIIT)

ACTIVE COMPARATOR

Behavioral: HIIT-only

A Single Bout Of Mindfulness

ACTIVE COMPARATOR

Behavioral: MF-only

A Single Bout Of Sitting Rest

OTHER

Behavioral: Sitting rest

Interventions

MF-HIIT BEHAVIORAL

A single bout of 20-min MF-HIIT protocol delivered through a motor-driven treadmill. The protocol will start with a 1.5-min warm-up, then a 16.5-min main exercise (6 x 90s exercise intervals separated by 5 x 90s mindful intervals), and finally a 2-min cool-down.

A Single Bout Of Mindful High-Intensity Interval Training (Mindful HIIT)

MF-only BEHAVIORAL

A single bout of 20-min intervention mindfulness intervention that includes 5 x 90s mindful intervals separated by sitting rest

A Single Bout Of Mindfulness

HIIT-only BEHAVIORAL

A single bout of 20-min HIIT protocol delivered through a motor-driven treadmill. The protocol will start with a 1.5-min warm-up, then a 16.5-min main exercise (6 x 90s exercise intervals separated by 5 x 90s rest intervals), and finally a 2-min cool-down.

A Single Bout Of High-Intensity Interval Training (HIIT)

Sitting rest BEHAVIORAL

Participants will sit in a comfortable chair, placed on the treadmill, while watching a HIIT video without mindfulness instructions for 20 minutes.

A Single Bout Of Sitting Rest

Eligibility Criteria

• Age: 10 Years - 12 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Age between 10-12 years old
• Intelligence Quotient ≥ 85
• Capable of performing exercise based on pre-participation health screening
• No formal diagnosis of cognitive disorders (e.g., attention deficit hyperactivity disorder) and neurological diseases (e.g., epilepsy)

You may not qualify if:

• Age outside of the range of 10-12 years old
• Intelligence Quotient \< 85
• No capable of performing exercise based on pre-participation health screening
• Has formal diagnosis of cognitive disorders (e.g., attention deficit hyperactivity disorder) and neurological diseases (e.g., epilepsy)

Sponsors & Collaborators

• Purdue University: lead
• University of Oregon: collaborator

Study Sites (1)

Lambert, 800 West Stadium Avenue

West Lafayette, Indiana, 47907, United States

RECRUITING

Central Study Contacts

Shih-Chun Kao, PhD

CONTACT

765-496-2213; kao28@purdue.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: January 29, 2024
• First Posted: February 21, 2024
• Study Start: June 15, 2024
• Primary Completion (Estimated): May 31, 2026
• Study Completion (Estimated): May 31, 2026
• Last Updated: April 23, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)