Wetting Solution-ideal Body Weight Ratio in Liposuction Procedures

NCT06260501 | Completed

• 1 other identifier: ATADEK-2023-13/463
• Study Type: observational
• Target: 192
• Locations: 1 country
• Sites: 1

Brief Summary

Although the use of wetting solutions during high-volume liposuction is a standard approach, it is unclear how to optimize wetting solutions and components and their effect on postoperative complications.. Since the super-wet technique (aspiration of 1 cc per 1 cc of infiltrate) was introduced in 1986, it has become one of the most frequently applied techniques worldwide . Adrenaline and lidocaine are often added to WS due to their hemostatic and analgesic effects One of the major advantages of super-wet technique is that blood loss is quite low. However, potential cardiovascular side effects of WS and the amounts of epinephrine and lidocaine they contain, such as volume overload, local anesthetic toxicity, hypertension, arrhythmia, and tachycardia, are still a scoop of investigation. In this study, we examined the WS and the medications it contains from a different perspective to understand the possible cause of these adverse outcomes. Despite the most suitable candidates for liposuction are patients with a BMI\<30 kg/m2 and low comorbidity and age, the patient group undergoing liposuction is often obese, and overweight individuals require that obesity-related pathophysiological changes be taken into consideration. Therefore, we analyzed the patients by dividing them into two groups according to the amount of WS applied according to their IBW (WS/IBW≤90ml/kg: group I and WS/IBW\>90ml/kg: group I). In this study we aimed to evaluate the effect of wetting solutions and components calculated according to ideal body weight (IBW) on postoperative complications

Conditions

Liposuction; Obesity; Postoperative Complications

Keywords

Liposuction; Obesity; Ideal body weight; Wetting solution; Epinephrine; Lidocaine

Outcome Measures

Primary Outcomes (2)

• Mean arterial pressure (MAP) was measured to detect hypertension and hypotension.

  MAP is a parameter used to evaluate blood pressure. If the MAP value was above 90 mm/hg, it was considered hypertension. If the MAP value was above 60 mm/hg, it was considered hypotension

  Duration of measurement was defined as one minute before anesthesia induction, during the surgery, and up to 2 days after surgery.

• The Numerical Pain Rating Scale (NRS) was used to assess postoperative pain level

  The Numerical Pain Rating Scale measures pain levels using a numerical scale from 0 to 10. 10 indicates the maximum value, and 0 indicates the minimum value. Values above 4 indicate a worse outcome, and values below 4 indicate a better outcome.

  Duration of measurement was defined as the period immediately after surgery and up to 2 days after the end of surgery.

Study Arms (1)

High volume liposuction under general anesthesia with super-wet technique

Patients who underwent high-volume liposuction with super-wet technique using wetting-solution containing 0.5 gr lidocaine and 0.5 mg epinephrine in each liter under general anesthesia

Other: super-wet technique

Interventions

super-wet technique OTHER

Liposuction with super-wet technique using wetting-solution containing 0.5 gr lidocaine and 0.5 mg epinephrine in each liter

High volume liposuction under general anesthesia with super-wet technique

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who underwent high-volume liposuction with super-wet technique under general anesthesia

You may qualify if:

• Patients with American Society Of Anesthesiology physical status 1-3
• Patients who underwent high-volume liposuction with super-wet technique

You may not qualify if:

• Patients under 18 years of age
• Patients with a history of allergy to local anesthetic agents

Sponsors & Collaborators

• Acibadem University: lead

Study Sites (1)

Acibadem Altunizade Hospital

Istanbul, Turkey (Türkiye)

Location

Related Publications (5)

• Obara S, Yoshida K, Inoue S. How obesity affects the disposition of intravenous anesthetics. Curr Opin Anaesthesiol. 2023 Aug 1;36(4):414-421. doi: 10.1097/ACO.0000000000001280. Epub 2023 Jun 8.

  PMID: 37314170 BACKGROUND

• Brown SA, Lipschitz AH, Kenkel JM, Sorokin E, Shepherd G, Grebe S, Oliver LK, Luby M, Rohrich RJ. Pharmacokinetics and safety of epinephrine use in liposuction. Plast Reconstr Surg. 2004 Sep 1;114(3):756-63; discussion 764-5. doi: 10.1097/01.prs.0000131021.17800.be.

  PMID: 15318058 BACKGROUND

• Hatef DA, Brown SA, Lipschitz AH, Kenkel JM. Efficacy of lidocaine for pain control in subcutaneous infiltration during liposuction. Aesthet Surg J. 2009 Mar-Apr;29(2):122-8. doi: 10.1016/j.asj.2009.01.014.

  PMID: 19371843 BACKGROUND

• Appelbaum N, Clarke J. Ideal body weight calculations: fit for purpose in modern anaesthesia? Eur J Anaesthesiol. 2021 Dec 1;38(12):1211-1214. doi: 10.1097/EJA.0000000000001515. No abstract available.

  PMID: 33876785 BACKGROUND

• Mendez BM, Coleman JE, Kenkel JM. Optimizing Patient Outcomes and Safety With Liposuction. Aesthet Surg J. 2019 Jan 1;39(1):66-82. doi: 10.1093/asj/sjy151.

  PMID: 29947738 RESULT

MeSH Terms

Conditions

Obesity; Postoperative Complications

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes

Study Officials

• Serap Aktas Yildirim, M.D.

  Acibadem Mehmet Ali Aydinlar University School of Medicine, Department of Anesthesiology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 5, 2024
• First Posted: February 15, 2024
• Study Start: September 1, 2021
• Primary Completion: September 30, 2023
• Study Completion: October 30, 2023
• Last Updated: February 15, 2024

Record last verified: 2024-02

Locations

TU (1)