The Relationship Between Anticholinergic Burden and Postoperative Complications After Cardiac Surgery in Older Adults

NCT05312684 | Unknown

• 1 other identifier: 22-2476
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Drugs with anticholinergic properties are widely prescribed in the elderly population, despite increasing evidence in the literature regarding side effects and adverse outcomes. As is known, many drugs have anticholinergic activity, which means that they block the binding of the neurotransmitter acetylcholine to the muscarinic receptor. In this case, the occurrence of anticholinergic side effects becomes inevitable. Central effects such as cognitive impairment, dizziness, sedation, confusion or delirium, and peripheral effects such as dry mouth, dry eyes, constipation, urinary retention, and tachycardia begin to be seen in patients. Anticholinergic load refers to the cumulative effect of taking one or more drugs with anticholinergic activity. This cumulative effect is a strong indicator of cognitive and physical deterioration, especially in the elderly population. It is also associated with adverse outcomes such as falls, impaired functioning, and higher rates of hospitalization and death. Anticholinergic load scales include scales that facilitate the work of physicians used in clinical practice to predict anticholinergic side effects in humans. Although there are many different scales used at this point, one of the scales with the highest validity and reliability in recent studies are Anticholinergic cognitive burden scale (ACB) and Anticholinergic risk scale (ARS). To the best of our knowledge, we could not find any study on postoperative complications, length of hospital stay and mortality after cardiac surgery with these scales. Therefore, we aimed to examine the relationship between possible complications after cardiac surgery and anticholinergic load scales showing the cumulative effect of preoperative drugs.

Conditions

Postoperative Complications

Outcome Measures

Primary Outcomes (1)

• Postoperative complication

  Dindo classification

  1 month fellow-up

Study Arms (2)

High anticholinergic burden

ACB scale score 1 or \>1 as a high anticholinergic buden

Procedure: cardiac surgery

Normal anticholinergic burden

ACB scale score \<1 as a control group

Procedure: cardiac surgery

Interventions

cardiac surgery PROCEDURE

cardiovascular surgery including valve repair/replacement or CABG or combined procedures

High anticholinergic burden; Normal anticholinergic burden

Eligibility Criteria

• Age: 65 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

It is planned to include patients over the age of 65 who underwent cardiac surgery in the study population.

You may qualify if:

• It is planned to include patients over the age of 65 who underwent cardiac surgery in the research population.
• Gender discrimination will not be considered.

You may not qualify if:

• Those who are under the age of 65,
• Those who have non-cardiac surgery,
• Those whose drug records cannot be accessed

Sponsors & Collaborators

• Gulhane Training and Research Hospital: lead

Study Sites (1)

Gulhane training and research hospital

Ankara, 06670, Turkey (Türkiye)

Location

Related Publications (1)

• Katipoglu B, Kurtbeyoglu S, Demir ZA, Mavioglu HL. The effect of the anticholinergic burden on mortality following elective cardiac surgery. Curr Med Res Opin. 2024 Jan;40(1):27-34. doi: 10.1080/03007995.2023.2288278. Epub 2024 Jan 3.

  PMID: 37999982 DERIVED

MeSH Terms

Conditions

Postoperative Complications

Interventions

Cardiac Surgical Procedures

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Cardiovascular Surgical Procedures; Surgical Procedures, Operative; Thoracic Surgical Procedures

Study Officials

• Bilal Katipoglu

  Gulhane Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Bilal Katipoglu, MD

CONTACT

+905543330380; drbilal07@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D

Study Record Dates

• First Submitted: March 28, 2022
• First Posted: April 5, 2022
• Study Start: April 1, 2022
• Primary Completion: September 1, 2022
• Study Completion: December 1, 2022
• Last Updated: April 5, 2022

Record last verified: 2022-03

Locations

TU (1)