Acute Pancreatitis : Comparison of Various Scores in Predicting Severity and Outcome

NCT06240338 | Not Yet Recruiting

• 1 other identifier: Soh-Med-23-12-05MD
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

The study will make a comparison between Various severity scoring systems that has been designed to assess the severity and predict prognosis in acute pancreatitis

Conditions

Acute Pancreatitis

Outcome Measures

Primary Outcomes (1)

• Comparison of various scores in predicting severity and outcome in patients with acute pancreatitis. 1.Homeostatic model assessment of insulin resistance. 2.The harmless acute pancreatitis score.

  1. Homeostatic model assessment of insulin resistance it measure severity of insulin resistance, there is an association between insulin resistance and severity of acute pancreatitis. It is defined as fasting glucose (mmol/L) × fasting insulin (μmol/L)/22.5\] or \[fasting glucose (mg/dL) × fasting insulin (μmol/L) Reference index levels is ≤ 2. If index ˃ 2 indicate presence of insulin resistance 2. The harmless acute pancreatitis score Harmless acute pancreatitis score contains three parameters - blood urea nitrogen, levels of serum creatinine and haematocrit . The patient is classified as harmless acute pancreatitis score negative (-) if they have blood urea nitrogen \<25 mg/dL, serum creatinine levels \< 2 mg/dL, and haematocrit levels of \<43% for males and \<39.6% for females at the time of admission. The patient is considered positive (+) if any one of the above parameters is positive.

  within 18 months

Interventions

laboratory investigation and Imaging DIAGNOSTIC_TEST

laboratory parameters (white blood cell count,neutrophil count, lymphocyte count, hemoglobin level, platelet level, red cell distribution width (RDW) level, hematocrit (HCT), renal function, hepatic function, electrolytes, arterial blood gas, HOMA-IR) will be assessed and imaging: Abdominal ultrasonography, Abdominal CT or MRI if needed

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

* age \<18 years old, * patients with metastatic tumor * late stage of liver cirrhosis * active tuberculosis * refractory heart failure * previous transplantation * immunosuppressive therapy * pregnancy * patients with chronic pancreatitis or pancreas carcinoma

You may qualify if:

• Any patient with 18 years or above and met criteria for diagnosis of acute pancreatitis will be eligible for the study.

Sponsors & Collaborators

• Sohag University: lead

MeSH Terms

Conditions

Pancreatitis

Interventions

Diagnostic Imaging

Condition Hierarchy (Ancestors)

Pancreatic Diseases; Digestive System Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques and Procedures; Diagnosis

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator of tropical medicine

Study Record Dates

• First Submitted: January 2, 2024
• First Posted: February 5, 2024
• Study Start: February 20, 2024
• Primary Completion: August 20, 2025
• Study Completion: August 20, 2025
• Last Updated: February 14, 2024

Record last verified: 2024-02