Incidence of Splanchnic Venous Thrombosis in Acute Pancreatitis and it's Correlation With Severity of Pancreatitis

NCT07322978 | Recruiting

• 1 other identifier: SVT in AP-01
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Acute pancreatitis (AP) is a common medical condition characterized by inflammation of the pancreas, affecting a significant portion of the population. With approximately one-third of patients experiencing notable morbidity due to local or systemic complications, the severity of the disease is underscored by the presence of acute peripancreatic fluid collections, acute necrotic collections, pseudocysts, and walled-off necrosis1. Notably, vascular complications, such as splanchnic vein thrombosis, further contribute to the increased morbidity and mortality associated with acute pancreatitis2. Splanchnic vein thrombosis encompasses thromboses in the splenic (SpVT), portal (PVT), and superior mesenteric veins (SMVT), either individually or in combination3. These complications are often incidentally discovered during imaging procedures conducted to assess potential complications4. Despite most cases being asymptomatic, fatal complications, including bowel ischemia, liver failure, portal hypertension, and life-threatening bleeding, have been documented, with the risk of splanchnic vein thrombosis escalating with the severity of pancreatitis

Conditions

Acute Pancreatitis

Outcome Measures

Primary Outcomes (1)

• Primary outcome

  Detection of thrombus in splenic, superior mesenteric or portal vein.

  1 year

Secondary Outcomes (4)

• Secondary Outcome

  1 year

• Secondary Outcome

  1 year

• Secondary Outcome

  1 year

• Secondary Outcome

  6 months

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All in-patients with acute pancreatitis, getting admitted from emergency or OPD will be enrolled. Only when a study subject has given informed consent, clinical data will be recorded

You may qualify if:

• Patients aged between 18-85 years of age.
• Diagnosis of AP as per international consensus criteria.

You may not qualify if:

• Chronic pancreatitis.
• Established malignancy.
• Cirrhosis of liver or established portal hypertension.
• Pregnancy.

Sponsors & Collaborators

• Asian Institute of Gastroenterology, India: lead

Study Sites (1)

AIG Hospital

Hyderabad, Telangana, 500032, India

RECRUITING

MeSH Terms

Conditions

Pancreatitis

Condition Hierarchy (Ancestors)

Pancreatic Diseases; Digestive System Diseases

Central Study Contacts

Sharath Sitaram, MBBS, DNB

CONTACT

8197016905; sharath.sitaram@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 2, 2025
• First Posted: January 7, 2026
• Study Start: February 27, 2025
• Primary Completion: February 27, 2026
• Study Completion: February 27, 2026
• Last Updated: January 7, 2026

Record last verified: 2025-02

Locations

IN (1)