Association Between Handgrip Strength and Small Airway Disease in Patients with Stable Chronic Obstructive Pulmonary Disease

NCT06223139 | Completed

• 1 other identifier: MTU-EC-IM-0-215/65
• Study Type: observational
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to investigate the correlation between handgrip strength and small airway disease among patients with chronic obstructive pulmonary disease (COPD). The main question it aims to answer is: • Is handgrip strength correlated with small airway disease in COPD patients? Participants will perform handgrip strength test and impulse oscillometry (IOS).

Conditions

COPD

Keywords

chronic obstructive pulmonary disease; handgrip strength; small airway disease; airway resistance; correlation

Outcome Measures

Primary Outcomes (1)

• Correlation between handgrip strength and small airway disease in COPD patients

  This correlation will be reported as correlation coefficient (R).

  At day 1 of the study

Secondary Outcomes (1)

• The best cutoff value of handgrip strength for predicting small airway disease in COPD patients

  At day1 of the study

Study Arms (1)

COPD

COPD patients aged 40 years or older with a post-bronchodilator ratio of forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) \<0.7.

Diagnostic Test: Handgrip strength

Interventions

Handgrip strength DIAGNOSTIC_TEST

Handgrip strength will be measured by 3 efforts.

COPD

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

COPD patients aged 40 years or older who are confirmed diagnosis by spirometry (post-bronchodilator FEV1/FVC \<0.7) and smoking history 10 pack-years or more.

You may qualify if:

• COPD patients aged 40 years or older
• Confirmed diagnosis by spirometry (post-bronchodilator FEV1/FVC \<0.7)
• Smoking history 10 pack-years or more

You may not qualify if:

• COPD exacerbation within 3 months
• Inability to perform handgrip strength test or impulse oscillometry

Sponsors & Collaborators

• Thammasat University: lead

Study Sites (1)

Thammasat University Faculty of Medicine

Pathum Thani, Changwat Pathum Thani, 12120, Thailand

Location

Related Publications (1)

• Keawon T, Saiphoklang N. Association between handgrip strength and small airway disease in patients with stable chronic obstructive pulmonary disease. Ther Adv Respir Dis. 2024 Jan-Dec;18:17534666241281675. doi: 10.1177/17534666241281675.

  PMID: 39367749 DERIVED

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Narongkorn Saiphoklang, MD

  Thammasat University Faculty of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Month
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: January 12, 2024
• First Posted: January 25, 2024
• Study Start: March 1, 2023
• Primary Completion: January 31, 2024
• Study Completion: May 31, 2024
• Last Updated: January 17, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP

Locations

TH (1)