The Role of Computed Tomography in the Phenotyping of COPD Patients
1 other identifier
observational
50
1 country
1
Brief Summary
Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease that is characterized by respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities usually caused by significant exposure to noxious particles or gases. the CT was used for classification of COPD patients into different phenotypes: phenotype A that has minimal emphysema with or without airway disease, phenotype E that has emphysema without airway disease, and finally phenotype M as a mixed form. The investigators aimed to to identify the phenotypes of COPD using radiologic data obtained by computed tomography. Moreover, this study will be designed to answer the questions about possible correlation between pulmonary function parameters and CT.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Apr 2022
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2022
CompletedFirst Submitted
Initial submission to the registry
February 17, 2023
CompletedFirst Posted
Study publicly available on registry
February 28, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 30, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2023
CompletedFebruary 2, 2024
February 1, 2024
12 months
February 17, 2023
February 1, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
Identifying the different phenotypes of COPD using HRCT
Identifying the different phenotypes of COPD using HRCT. moreover, to identify whether there is a possible correlation between CT phenotypes and FEV1, FVC or FEV1/FVC.
one month
Interventions
All patients will undergo MSCT chest at both inspiratory and expiratory phases in supine position without any contrast media.
Eligibility Criteria
• All stable COPD patients that lastly confirmed to have the disease based on spirometry and past clinical history according to GOLD (2022).and able to perform MSCT
You may qualify if:
- All stable COPD patients that lastly confirmed to have the disease based on spirometry and past clinical history according to GOLD (2022).
- Age above 18 years.
You may not qualify if:
- COPD patients associated with other chest diseases as collapse
- COPD patients associated with consolidation
- COPD patients unable to perform spirometry
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Aswan Universitylead
Study Sites (1)
Islam Galal Sayed
Asyut, Egypt
Related Publications (1)
Fan L, Xia Y, Guan Y, Zhang TF, Liu SY. Characteristic features of pulmonary function test, CT volume analysis and MR perfusion imaging in COPD patients with different HRCT phenotypes. Clin Respir J. 2014 Jan;8(1):45-54. doi: 10.1111/crj.12033. Epub 2013 Jul 31.
PMID: 23711228BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 1 Year
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
February 17, 2023
First Posted
February 28, 2023
Study Start
April 1, 2022
Primary Completion
March 30, 2023
Study Completion
December 31, 2023
Last Updated
February 2, 2024
Record last verified: 2024-02