Investigation of Effects of Delayed Feedback on Non-motor Symptoms in Individuals With Parkinson's Disease

NCT06217484 | Completed

• 1 other identifier: E-1228-23
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Learning deficits are frequent in individuals with Parkinson's Disease. Clear feedback is integral because through feedback individuals know whether they should stick with an action that they have been doing (if the feedback is positive), or change their course of action (if the feedback is negative). Learning though immediate feedback has been shown to be depended on the brain chemical dopamine that is disrupted in individuals with Parkinson's Disease. During learning, feedback can also be presented after a delay. The investigators propose that learning through delayed feedback will lead to greater learning in individuals with Parkinson's Disease, since learning through delayed feedback does not rely on dopamine. During the proposed paradigm, participants with Parkinson's Disease complete a multiple-choice test. After making their selection on the multiple-choice test, they either see feedback immediately or are given feedback 25 minute later after reviewing their selection on the multiple-choice test. The investigators hypothesize that participants will learn better when they are provided with delayed feedback.

Conditions

Parkinson Disease

Keywords

Parkinson Disease; learning; feedback

Outcome Measures

Primary Outcomes (1)

• Percent correct responses will be collected through the computer software

  Response accuracy per trial

  testing lasts 60 minutes and completed in 1 day

Study Arms (1)

Parkinson Disease

Participants with Parkinson Disease; Single group.

Behavioral: delayed feedback

Interventions

delayed feedback BEHAVIORAL

participants learn through either immediate or delayed feedback during a computer task

Parkinson Disease

Eligibility Criteria

• Age: 55 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Individuals with Parkinson Disease

You may qualify if:

• Only participants with scores above 24/30 on the Montreal Cognitive Assessment will be recruited for participation to exclude dementia.

You may not qualify if:

• Individuals with neurological conditions other than PD such as epilepsy, multiple sclerosis, brain tumors, etc. will be excluded to control for the effects these conditions have on the brain and behavior.

Sponsors & Collaborators

• Kessler Foundation: lead

Study Sites (1)

Kessler Foundation

East Hanover, New Jersey, 07936, United States

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Ekaterina Dobryakova, PhD

  Kessler Foundation

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Director of Neuroscience Research

Study Record Dates

• First Submitted: December 28, 2023
• First Posted: January 22, 2024
• Study Start: September 1, 2023
• Primary Completion: April 1, 2025
• Study Completion: May 31, 2025
• Last Updated: September 5, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)