NCT05917704

Brief Summary

The purpose of this study is to understand if training Parkinson's disease patients in classical guitar will improve motor function, mood, and quality of life. While medication has been found to be effective for many Parkinson's disease patients, many patients still have symptoms. Previous studies have found that music and rhythm-based activities can help Parkinson's disease symptoms. A previous study looked at the effect of playing classical guitar on Parkinson's disease symptoms. They found positive changes in Parkinson's disease symptoms that lasted for 6 weeks after the study ended. Further, there were positive changes in depression, anxiety, and quality of life.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
40

participants targeted

Target at P50-P75 for not_applicable parkinson-disease

Timeline
Completed

Started Jun 2023

Shorter than P25 for not_applicable parkinson-disease

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 6, 2023

Completed
Same day until next milestone

Study Start

First participant enrolled

June 6, 2023

Completed
20 days until next milestone

First Posted

Study publicly available on registry

June 26, 2023

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 12, 2023

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2024

Completed
Last Updated

June 26, 2023

Status Verified

June 1, 2023

Enrollment Period

6 months

First QC Date

June 6, 2023

Last Update Submit

June 14, 2023

Conditions

Parkinson Disease

Keywords

Parkinson's diseasemusic-based therapy

Outcome Measures

Primary Outcomes (1)

  • Change in the motor subscore of the Movement Disorder Society Unified Parkinson's Disease Rating Scale Motor Subscale

    Change in Parkinson's disease rating scale, range 0-32, higher score means more severe Parkinson's disease symptoms

    Baseline, 6 weeks, 12 weeks

Secondary Outcomes (6)

  • Change in Parkinson's disease Questionnaire-39

    Baseline, 6 weeks, 12 weeks

  • Change in percent of day with tremor

    Baseline, 6 weeks, 12 weeks

  • Change in Beck Depression Inventory-II

    Baseline, 6 weeks, 12 weeks

  • Change in Apathy evaluation scale total score

    Baseline, 6 weeks, 12 weeks

  • Change in American Parkinson's disease Association symptom tracker score

    Baseline, 6 weeks, 12 weeks

  • +1 more secondary outcomes

Study Arms (2)

Guitar then physical therapy

ACTIVE COMPARATOR

Subjects will learn classical guitar then have physical therapy sessions.

Other: Guitar then physical therapy

Physical therapy then guitar

ACTIVE COMPARATOR

Subjects will have physical therapy sessions then learn classical guitar

Other: Physical therapy then guitar

Interventions

Guitar then physical therapyOTHER

See arm/group descriptions

Guitar then physical therapy
Physical therapy then guitarOTHER

See arm/group descriptions

Physical therapy then guitar

Eligibility Criteria

Age50 Years - 90 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years old
  • Diagnosis with Parkinson's disease by a Movement Disorder specialist

You may not qualify if:

  • Professional musician or formal music training
  • Inability to play a classical guitar physically
  • Inability to follow instruction
  • Receiving physical therapy at the time of the study
  • Unable to attend all sessions of study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Northwest Chapter of the American Parkinson Disease Association

Seattle, Washington, 98109, United States

RECRUITING

Related Publications (1)

  • Adams C, Fulton G. A Cross-over Pilot Study on the Effects of Classical Guitar Instruction on Motor and Non-Motor Symptoms in People with Parkinson's Disease. Neurosci Insights. 2025 Mar 24;20:26331055251329878. doi: 10.1177/26331055251329878. eCollection 2025.

    PMID: 40143890DERIVED

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian DisordersBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMovement DisordersSynucleinopathiesNeurodegenerative Diseases

Study Officials

  • Christopher Adams, MS, MD

    University of Washington

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Christopher Adams, MS, MD

CONTACT

206-616-5207caadams1@uw.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Acting Instructor

Study Record Dates

First Submitted

June 6, 2023

First Posted

June 26, 2023

Study Start

June 6, 2023

Primary Completion

December 12, 2023

Study Completion

February 1, 2024

Last Updated

June 26, 2023

Record last verified: 2023-06

Locations

US(1)