Renal Resistive Index in Septic Shock Patients

NCT06214715 | Unknown

• 1 other identifier: BVU-AR-MR-001
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Septic shock is a condition of acute circulatory failure and is defined as a process that requires the use of vasopressors to ensure adequate tissue perfusion when hypotension develops. It is mainly characterized by abnormal peripheral vascular resistance; Therefore, improving vascular function and organ damage is crucial in the management of septic shock. Blood flow measurement with Doppler-based renal resistive index (RRI), which can be performed at the bedside, especially in renal abnormalities, is currently accepted as a tool to assess renal perfusion. With this simple, rapid and reproducible technique, the investigators determine RRI by evaluating systolic and diastolic blood velocity from Doppler flow waveforms in the intrarenal arcuate or interlobar arteries. Our aim is to investigate the relationship between renal resistive index (RRI) and global tissue hypoperfusion parameters and clinical outcomes in septic shock patients admitted to the intensive care unit and receiving invasive mechanical ventilator support.

Conditions

Septic Shock

Outcome Measures

Primary Outcomes (1)

• Renal resistive index

  The renal arterial resistive index (RI) is a sonographic index of intrarenal arteries defined as (peak systolic velocity - end-diastolic velocity) / peak systolic velocity. The normal range is 0.50-0.70

  24 hour

Interventions

Philips ultrasonography system DEVICE

RRI will be measured by renal ultrasonography with a C5-1 convex probe using a Philips ultrasonography model device.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

It is planned for patients who are admitted due to septic shock and need invasive mechanical ventilator support, who have a central venous catheter inserted for central venous pressure measurement and advanced monitoring, and who have undergone invasive arterial monitoring for close hemodynamic monitoring.

You may qualify if:

• Followed up due to sepsis
• In need of intensive care follow-up
• In need of invasive mechanical ventilation
• Sofa score \>2

You may not qualify if:

• Hypothermic patients (\<35C)
• with chronic renal failure
• Pregnant women
• Those with renal artery stenosis
• Structural kidney damage
• Patient with previous renal surgery
• Intra-abdominal postoperative surgery patients
• Patients with atrial fibrillation

Sponsors & Collaborators

• Bezmialem Vakif University: lead

Study Sites (1)

Bezmialem Vakıf University

Istanbul, 34000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Shock, Septic

Condition Hierarchy (Ancestors)

Sepsis; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Study Officials

• Monira Rahim, M.D.

  Bezmialem Vakif University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 10, 2024
• First Posted: January 22, 2024
• Study Start: October 20, 2023
• Primary Completion: January 30, 2024
• Study Completion: December 2, 2024
• Last Updated: January 24, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)