Patterns of Neurodevelopmental Disorders

NCT06213090 | Recruiting

• 1 other identifier: NeuroClinical
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders.

Conditions

Autism Spectrum Disorder; Pediatric Acute-Onset Neuropsychiatric Syndrome; Down Syndrome; Epilepsy; Mitochondrial Encephalomyopathies; Cerebral Folate Deficiency; Neurodevelopmental Disorders; Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection

Outcome Measures

Primary Outcomes (1)

• Number of Patients with Specific Medical abnormalities

  It is unknown if a specific set of biological abnormalities contribute to the formation of many types of neurodevelopmental disorders. The study is intended to identify the relationship between biological abnormalities and neurodevelopmental disorders. The chart will be reviewed for medical diagnoses other than the primary neurodevelopmental disorders.

  up to 7 years

Secondary Outcomes (2)

• The number of children with abnormal clinical lab

  up to 7 years

• The number of children who respond to specific treatments

  up to 7 years

Study Arms (10)

Autism

Children with autism will be followed in regards to their clinical management.

Mitochondrial Encephalopathy

Children with Mitochondrial Encephalopathy will be followed in regards to their clinical management.

Down Syndrome

Children with Down Syndrome will be followed in regards to their clinical management.

Cerebral Folate Deficiency

Children with Cerebral Folate Deficiency will be followed in regards to their clinical management.

PANS

Children with PANS will be followed in regards to their clinical management.

PANDAS

Children with PANDAS will be followed in regards to their clinical management.

Epilepsy

Children with Epilepsy will be followed in regards to their clinical management.

ADHD

Children with ADHD will be followed in regards to their clinical management.

Dyslexia and other learning disabilities

Children with Dyslexia and other learning disabilities will be followed in regards to their clinical management.

Other Neurodevelopmental Disorders

Children with Other Neurodevelopmental Disorders will be followed in regards to their clinical management.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Children who present to Rossignol Medical Center for standard care related to neurodevelopmental disorders.

You may qualify if:

• Neurodevelopmental delays Clinical visit at an Rossignol Medical Center

Sponsors & Collaborators

• Richard Frye: lead
• Autism Discovery and Treatment Foundation: collaborator

Study Sites (1)

Rossignol Medical Center

Phoenix, Arizona, 85050, United States

RECRUITING

Related Links

• Rossignol Medical Center
• Autism Discovery and Treatment Foundation

Biospecimen

Retention: SAMPLES WITH DNA

Blood, urine, cerebrospinal fluid, muscle, and skin samples may be retained.

MeSH Terms

Conditions

Neurodevelopmental Disorders; Autism Spectrum Disorder; Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections; Pediatric acute-onset neuropsychiatric syndrome; Down Syndrome; Epilepsy; Mitochondrial Encephalomyopathies; Neurodegeneration Due To Cerebral Folate Transport Deficiency

Condition Hierarchy (Ancestors)

Mental Disorders; Child Development Disorders, Pervasive; Intellectual Disability; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Abnormalities, Multiple; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Chromosome Disorders; Genetic Diseases, Inborn; Brain Diseases; Central Nervous System Diseases; Mitochondrial Myopathies; Muscular Diseases; Musculoskeletal Diseases; Brain Diseases, Metabolic; Neuromuscular Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Mitochondrial Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 4, 2024
• First Posted: January 19, 2024
• Study Start: February 1, 2024
• Primary Completion (Estimated): December 31, 2030
• Study Completion (Estimated): December 31, 2030
• Last Updated: April 16, 2026

Record last verified: 2026-04

Locations

US (1)