Admission Pattern Among Children With Gastro-intestinal Infections Before and During the Covid-19 Pandemic

NCT06211621 | Completed

• 1 other identifier: R-21041034
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

During the Covid-19 pandemic, admission patterns for infections other than Covid-19 have changed dramatically among children worldwide. Particularly admissions due to respiratory infections and later invasive streptococcal infections have been well documented. However, few studies have compared rates af gastro-intestinal infections during the pandemic with the previous years. This study aims to compare the number and characteristics of children hospitalized with gastrointestinal infections before the COVID-19 pandemic, to the first strict lockdown in 2020 and to the second, less strict lockdown in 2021. A retrospective review of medical records will be performed, of patients aged 1 month to 5 years admitted with gastroenteritis at the pediatric department at Slagelse Hospital in Denmark over a period from 2017 to 2021.

Conditions

Gastroenteritis; Rota Virus Gastroenteritis; Dehydration in Children; Infectious Disease; COVID-19 Pandemic; Norovirus Infections

Keywords

gastroenteritis; indirect effects; lockdown; epidemic; pandemic; children; Denmark; dehydration; diarrhea

Outcome Measures

Primary Outcomes (1)

• incidence of admission with gastroeneteritis in children

  number of children admitted/1000 children per month

  five years (2017 to 2021)

Secondary Outcomes (2)

• age of children admitted

  five years (2017 to 2021)

• severity of illness

  five years (2017 to 2021)

Eligibility Criteria

• Age: 1 Month - 59 Months
• Sex: all
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

Children aged \>1 month and \<5 years admitted with symptoms of gastroenteritis at Slagelse Hospital during the months of january-june of 2017, 2018, 2019, 2020 and 2020

You may qualify if:

• Children admitted to Slagelse hospital
• aged \>1 month and \<5 years
• symptoms of gastrointestinal infection
• admitted during the months of january-june of 2017, 2018, 2019, 2020 and 2020

You may not qualify if:

• none

Sponsors & Collaborators

• Region Zealand: lead

Study Sites (1)

Department of Paediatrics and Adolescent Medicine

Slagelse, 4200, Denmark

Location

Related Publications (7)

• Gavish R, Krause I, Goldberg L, Bilavsky E, Kadmon G, Livni G, Scheuerman O, Levinsky Y. A Drop in Number of Hospitalizations Among Children with Bacterial Infections During the COVID-19 Pandemic. Pediatr Infect Dis J. 2021 Jan;40(1):e39-e41. doi: 10.1097/INF.0000000000002963.

  PMID: 33093429 BACKGROUND

• Kadambari S, Abo YN, Phuong LK, Osowicki J, Bryant PA. Decrease in Infection-related Hospital Admissions During COVID-19: Why Are Parents Avoiding the Doctor? Pediatr Infect Dis J. 2020 Nov;39(11):e385-e386. doi: 10.1097/INF.0000000000002870. No abstract available.

  PMID: 32852351 BACKGROUND

• Kamrath C, Monkemoller K, Biester T, Rohrer TR, Warncke K, Hammersen J, Holl RW. Ketoacidosis in Children and Adolescents With Newly Diagnosed Type 1 Diabetes During the COVID-19 Pandemic in Germany. JAMA. 2020 Aug 25;324(8):801-804. doi: 10.1001/jama.2020.13445.

  PMID: 32702751 BACKGROUND

• Foley DA, Yeoh DK, Minney-Smith CA, Martin AC, Mace AO, Sikazwe CT, Le H, Levy A, Moore HC, Blyth CC. The Interseasonal Resurgence of Respiratory Syncytial Virus in Australian Children Following the Reduction of Coronavirus Disease 2019-Related Public Health Measures. Clin Infect Dis. 2021 Nov 2;73(9):e2829-e2830. doi: 10.1093/cid/ciaa1906. No abstract available.

  PMID: 33594407 BACKGROUND

• Polcwiartek LB, Polcwiartek C, Andersen MP, Ostergaard L, Broccia MD, Gislason GH, Kober L, Torp-Pedersen C, Schou M, Fosbol E, Kragholm K, Hagstrom S. Consequences of coronavirus disease-2019 (COVID-19) lockdown on infection-related hospitalizations among the pediatric population in Denmark. Eur J Pediatr. 2021 Jun;180(6):1955-1963. doi: 10.1007/s00431-021-03934-2. Epub 2021 Feb 8.

  PMID: 33555426 BACKGROUND

• Nygaard U, Hartling UB, Nielsen J, Vestergaard LS, Dungu KHS, Nielsen JSA, Sellmer A, Matthesen AT, Kristensen K, Holm M. Hospital admissions and need for mechanical ventilation in children with respiratory syncytial virus before and during the COVID-19 pandemic: a Danish nationwide cohort study. Lancet Child Adolesc Health. 2023 Mar;7(3):171-179. doi: 10.1016/S2352-4642(22)00371-6. Epub 2023 Jan 9.

  PMID: 36634692 BACKGROUND

• Fischer TK, Rungoe C, Jensen CS, Breindahl M, Jorgensen TR, Nielsen JP, Jensen L, Malon M, Braendholt V, Fisker N, Hjelt K. The burden of rotavirus disease in Denmark 2009-2010. Pediatr Infect Dis J. 2011 Jul;30(7):e126-9. doi: 10.1097/INF.0b013e3182145277.

  PMID: 21386748 BACKGROUND

MeSH Terms

Conditions

Gastroenteritis; Communicable Diseases; COVID-19; Caliciviridae Infections; Dehydration; Diarrhea

Condition Hierarchy (Ancestors)

Gastrointestinal Diseases; Digestive System Diseases; Infections; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Water-Electrolyte Imbalance; Metabolic Diseases; Nutritional and Metabolic Diseases; Signs and Symptoms, Digestive; Signs and Symptoms

Study Officials

• Maren Rytter, PhD

  Region Sjæland, Slagelse Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant, PhD, clinical associate professor

Study Record Dates

• First Submitted: December 29, 2023
• First Posted: January 18, 2024
• Study Start: January 1, 2017
• Primary Completion: December 1, 2023
• Study Completion: January 1, 2024
• Last Updated: January 18, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will share

Locations

DK (1)