NCT06206694

Completed

Serum YKL-40 Levels is Associated With Nutritional and Oxida...

Tungs' Taichung Metroharbour Hospital Source

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Other study identifiers

Sponsor study identifier

112049

Study Type

observational

Actual enrollment (reported)

226

Locations

1 country

Sites

1

Timeline

Study Start

May 2, 2024

Actual (reported)

Primary Completion

December 31, 2024

Actual (reported)

Study Completion

December 31, 2024

Actual (reported)

Brief Summary

Background YKL-40 is a glycoprotein that had been reported to be associated with inflammation atherosclerosis and endothelial dysfunction. The objective is to explore the association of serum YKL-40 levels with nutrition status, inflammation, and body composition in a cohort of hemodialysis patients Methods We plan to recruit 400 prevalent HD patients. Their baseline serum YKL-40 levels, body anthropometry, the profile of insulin resistance, bioimpedance spectroscopy parameters, and nutritional indices will be measured.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 226 participants
Study completion date: December 31, 2024
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

First Submitted
January 4, 2024
Actual (reported)
First Posted
January 16, 2024
Actual (reported)
Study Start
May 2, 2024
Actual (reported)
Primary Completion
December 31, 2024
Actual (reported)
Study Completion
December 31, 2024
Actual (reported)

Last Updated: June 6, 2025
Status Verified: June 2025
Last Update Submitted: June 4, 2025

Conditions

Malnutrition Oxidative Stress

Keywords

YKL-40nutrition statushemodialysis patientsinflammation

Outcome Measures

Primary Outcomes (2)

Analysis of biomarkers of YKL40
YKL40 is also reportedly useful as an inflammation marker in HD patients
1 years
Evaluation of nutritional status and body composition
Malnutrition, with a prevalence between 40% and 75% in maintenance hemodialysis patients is the most important risk factor for morbidity, the quality of life, all-cause mortality and cardiovascular mortality.
1 years

Secondary Outcomes (7)

Analysis of biomarkers of IL-6
1 years
vaspin
1 years
insulin
1 years
adiponectin
1 years
total antioxidant capacity
1 years
+2 more secondary outcomes

Eligibility Criteria

Age20 Years+

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodProbability Sample

Study Population

patients have to be at least 20-years-old and hemodialysis (HD) for at least 3 months.

You may qualify if:

Both sexes aged 20 years or over

Sponsors & Collaborators

Tungs' Taichung Metroharbour Hospital
Otherlead

Study Sites (1)

Tungs' Taichung MetroHarbour Hospital

Taichung, Taiwan

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum

MeSH Terms

Conditions

MalnutritionInflammation

Condition Hierarchy (Ancestors)

Nutrition DisordersNutritional and Metabolic DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

Paik Seong Lim, PhD
Tungs' Taichung Metroharbour Hospital
PRINCIPAL INVESTIGATOR

Enrollment

226 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: CROSS SECTIONAL
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

January 4, 2024

First Posted

January 16, 2024

Study Start

May 2, 2024

Actual (reported)

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Received stable hemodialysis at least 3 months.

Written informed consent.

You may not qualify if:

heart failure
infection
cirrhosis
respiratory disease
nephrotic syndrome
malignancy
chronic liver disease
severe inflammation
None of the patients are receiving surgical operations or hospitalized in recent 3 months.

Contact the study team to confirm eligibility.

Primary Completion

December 31, 2024

Actual (reported)

Study Completion

December 31, 2024

Actual (reported)

Last Updated

June 6, 2025

Record last verified: 2025-06

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT06206694
Data provider: ClinicalTrials.gov
Source updated: 2025-06-06
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:40:17 UTC

Locations

TW(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Secondary Outcomes (7)

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations