Focused Ultrasound Thalamotomy for Tremor Relief in Atypical Parkinsonism

NCT06204575 | Completed

• 1 other identifier: RMB-0404-17
• Study Type: observational
• Target: 8
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this retrospective observational study is to describe the efficacy of focused ultrasound ventral-intermediate nucleus thalamotomy in patients with atypical parkinsonism.

• Is this treatment efficacious in patients with multiple system atrophy?
• Is this treatment efficacious in patients with diffuse Lewy Body Dementia? Data will be collected from patients charts.

Conditions

Atypical Parkinsonism; Dementia With Lewy Bodies; Multiple System Atrophy, MSA

Keywords

focused ultrasound; tremor; surgery; thalamotomy

Outcome Measures

Primary Outcomes (1)

• Clinical Rating Scale for Tremor

  tremor assessment by Clinical Rating Scale for Tremor. Scores ranging from 0 to 156, with higher scores indicating more severe tremor.

  baseline, pre-procedure, 1 month, 6 months and 1 year following procedure

Interventions

Data collection OTHER

Data collection

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients that underwent FUS VIM-thalamotomy and suffered from MSA or DLBD

You may not qualify if:

• Patients that did not underwent FUS ventral-intermediate nucleus thalamotomy
• Patients that underwent FUS ventral-intermediate nucleus thalamotomy and do not suffer from MSA or DLBD

Sponsors & Collaborators

• Rambam Health Care Campus: lead

Study Sites (1)

Rambam Health Care Campus

Haifa, 3109601, Israel

Location

MeSH Terms

Conditions

Lewy Body Disease; Multiple System Atrophy; Thyroid Dyshormonogenesis 2A; Tremor

Interventions

Data Collection

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Dementia; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders; Primary Dysautonomias; Autonomic Nervous System Diseases; Dyskinesias; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director Movement Disorders Institute, clinical senior lecturer, Chair of Neurology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology Haifa, Israel

Study Record Dates

• First Submitted: December 31, 2023
• First Posted: January 12, 2024
• Study Start: November 1, 2013
• Primary Completion: May 31, 2023
• Study Completion: May 31, 2023
• Last Updated: January 12, 2024

Record last verified: 2024-01

Locations

IL (1)