NCT03760705

Brief Summary

The research project aims to perform data extraction, integration and analysis across multiple clinical, administrative, financial and pharmacy databases in the participating institutions. The key data components will include clinical cardiovascular specific data, procedural data, financial and administrative data (e.g. cost of medications and supplies, length of stay, diagnosis codes etc.), short-to-long term clinical outcomes (including hospital re-admissions, cardiovascular events, death), and quality-of-care indices (e.g. compliance to guideline-recommended therapy and medications). The research project will involve all patients proven and/or suspected with coronary artery disease (CAD), congestive heart failure (CHF) and atrial fibrillation (AF) admitted to National Heart Centre Singapore (NHCS) and NUH.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
7,205,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2013

Longer than P75 for all trials

Geographic Reach
1 country

13 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 5, 2013

Completed
4.8 years until next milestone

First Submitted

Initial submission to the registry

April 4, 2018

Completed
8 months until next milestone

First Posted

Study publicly available on registry

November 30, 2018

Completed
7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2025

Completed
Last Updated

March 24, 2020

Status Verified

December 1, 2019

Enrollment Period

12.4 years

First QC Date

April 4, 2018

Last Update Submit

March 20, 2020

Conditions

Coronary Artery DiseaseCongestive Heart FailureAtrial Fibrillation

Keywords

CADCHFAFSingCLOUDCardiovascularRetrospectiveBRAINHDGDatabase

Outcome Measures

Primary Outcomes (3)

  • The primary outcome measure will be to assess the total number of patients who passed away due to any cause at the 1-year time point

    Mortality

    1 year

  • The primary outcome measure will be to assess the total number of patients who passed away due to any cause at the 2-year time point

    Mortality

    2 year

  • The primary outcome measure will be to assess the total number of patients who passed away due to any cause at the 3-year time point

    Mortality

    3 year

Secondary Outcomes (3)

  • The secondary outcome measure will be to assess the total number of patients who had major adverse cardiac event (MACE) due to any cause at the 1-year time point

    1 year

  • The secondary outcome measure will be to assess the total number of patients who had MACE due to any cause at the 2-year time point

    2 year

  • The secondary outcome measure will be to assess the total number of patients who had MACE due to any cause at the 3-year time point

    3 year

Study Arms (3)

Coronary Artery Disease

1. Clinical data collected by Singapore Cardiac Data Bank (SCDB) 2. Clinical, administrative, pharmacy, financial data collected by each participating hospital 3. Administrative data collected by the Ministry of Health

Other: Data Collection

Heart Failure

1. Clinical data collected by Singapore Cardiac Data Bank (SCDB) 2. Clinical, administrative, pharmacy, financial data collected by each participating hospital 3. Administrative data collected by the Ministry of Health

Other: Data Collection

Atrial Fibrillation

1. Clinical data collected by Singapore Cardiac Data Bank (SCDB) 2. Clinical, administrative, pharmacy, financial data collected by each participating hospital 3. Administrative data collected by the Ministry of Health

Other: Data Collection

Interventions

Data CollectionOTHER

1. Collection of data as detailed below: 1. Clinical data collected by SCDB 2. Clinical, administrative, pharmacy, financial data collected by each participating hospital 3. Administrative data collected by MOH 2. Data will be extracted and anonymized on a secure healthcare analytics platform 3. Collaboration with the MOH for collection of administrative and financial data 4. Analysis on how healthcare behavior is affected by education, socioeconomic level and other social or cultural factors. 5. Statistical Analysis by the bio statistical team. This team will be responsible for collecting and merging the collected data and will also ensure the quality of the data.

Atrial FibrillationCoronary Artery DiseaseHeart Failure

Eligibility Criteria

Age21 Years - 120 Years
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

The participating institutions will include National Heart Centre Singapore, National University Heart Centre, Singapore General Hospital, Tan Tock Seng Hospital, Changi General Hospital, Khoo Teck Puat Hospital, Ng Teng Fong General Hospital, Singhealth Polyclinics, National Healthcare Group Polyclinics, Sengkang General Hospital, National University Polyclinics, Alexandra Hospital, and the Ministry of Health Health Services Research Division. All patients who present to a healthcare institution with either CAD or suspected CAD (including chest pain); CHF or suspected CHF; AF or suspected AF

You may qualify if:

  • all patients who present to a healthcare institution with either CAD or suspected CAD (including chest pain); CHF or suspected CHF; AF or suspected AF

You may not qualify if:

  • non-Singaporeans

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (13)

National University Hospital (Singapore) Pte Ltd

Singapore, 119074, Singapore

Location

National Healthcare Group Polyclinics

Singapore, 138543, Singapore

Location

SingHealth Polyclinics

Singapore, 150167, Singapore

Location

Alexandra Hospital

Singapore, 159964, Singapore

Location

Singapore General Hospital

Singapore, 169608, Singapore

Location

National Heart Centre Singapore

Singapore, 169609, Singapore

Location

Ministry of Health

Singapore, 169854, Singapore

Location

Tan Tock Seng Hospital Pte Ltd

Singapore, 308433, Singapore

Location

Changi General Hospital

Singapore, 529889, Singapore

Location

National University Polyclinics

Singapore, 609606, Singapore

Location

Ng Teng Fong General Hospital

Singapore, 609606, Singapore

Location

Khoo Teck Puat Hospital

Singapore, 768828, Singapore

Location

Sengkang Hospital

Singapore, Singapore

Location

MeSH Terms

Conditions

Coronary Artery DiseaseHeart FailureAtrial Fibrillation

Interventions

Data Collection

Condition Hierarchy (Ancestors)

Coronary DiseaseMyocardial IschemiaHeart DiseasesCardiovascular DiseasesArteriosclerosisArterial Occlusive DiseasesVascular DiseasesArrhythmias, CardiacPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Epidemiologic MethodsInvestigative TechniquesHealth Care Evaluation MechanismsQuality of Health CareHealth Care Quality, Access, and EvaluationPublic HealthEnvironment and Public Health

Study Officials

  • Khung Keong Yeo

    National Heart Centre Singapore

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
OTHER
Target Duration
1 Day
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 4, 2018

First Posted

November 30, 2018

Study Start

July 5, 2013

Primary Completion

December 1, 2025

Study Completion

December 1, 2025

Last Updated

March 24, 2020

Record last verified: 2019-12

Data Sharing

IPD Sharing
Will not share

Locations

SG(13)