Correlation Between Psychological Resilience and Genetic, Inflammatory Indicators

NCT06193005 | Unknown

• 1 other identifier: SDHMC-231202
• Study Type: observational
• Target: 400
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this observational study is to evaluate and analyze the influencing factors of the adaptive ability of young people, explore the impact of the interaction of environment and gene on the psychological adaptive ability of young people, incorporate the prediction model of the dynamic change of adaptive ability, build a standardized norm of young people's adaptive ability, and form a grading reference standard system. The main questions it aims to answer are:

• What are most important influencing factors for the adaptive ability of young people?
• How the environment and gene interact with each other on the psychological adaptive ability of young people?
• Can we build a prediction model of the dynamic change of adaptive ability and form a grading reference standard system? Participants will support us with basic information data, adaptive ability assessment data, genetic testing data, brain image scanning data, and inflammatory indicators data. Then subjects were divided into very low adaptive group, low adaptive group, high adaptive group and very high adaptive group according to the quartile of adaptive ability score. And the statistical analysis will be performed by the data analyst.

Conditions

Genetic Predisposition to Disease; Environment; Adaptation, Psychological; Inflammation

Outcome Measures

Primary Outcomes (1)

• the Assessment of the Psychological Resillience

  Psychological Resillience was evaluated across multiple dimensions, including cognitive functioning, stress coping, psychological well-being, and personality traits, and was measured using internationally accepted scales. Psychological Resillience is measured using the Psychological Resilience Scale (CD-RISC), which consists of 25 items rated on a 5-point Richter's scale, with scores ranging from 0 to 4 indicating that this is not the case at all, seldom the case, sometimes the case, often the case, and almost always the case. The sum of the scores of the items is the total score of the scale, and the total score is 0\~100, the larger the score indicates the higher the level of psychological resilience, and the score of less than 60 is the poor level of psychological resilience, 61\~69 is the average level of psychological resilience, 70\~79 is the good level of psychological resilience, and \>=80 is the excellent level of psychological resilience.

  1 year

Study Arms (4)

very low adaptive group

The subjects were divided into very low adaptive group, low adaptive group, high adaptive group and very high adaptive group according to the quartile of adaptive ability score.

Other: no intervention

low adaptive group

The subjects were divided into very low adaptive group, low adaptive group, high adaptive group and very high adaptive group according to the quartile of adaptive ability score.

Other: no intervention

high adaptive group

The subjects were divided into very low adaptive group, low adaptive group, high adaptive group and very high adaptive group according to the quartile of adaptive ability score.

Other: no intervention

very high adaptive group

The subjects were divided into very low adaptive group, low adaptive group, high adaptive group and very high adaptive group according to the quartile of adaptive ability score.

Other: no intervention

Interventions

no intervention OTHER

no intervention

high adaptive group; low adaptive group; very high adaptive group; very low adaptive group

Eligibility Criteria

• Age: 18 Years - 24 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

18-24 years old young people

You may qualify if:

• Age 18-24 years old; high school graduation and above; agree to collect blood samples and sign an informed consent form.

You may not qualify if:

• Did not consent to the collection of blood samples; did not sign an informed consent form; suffered from a major illness such as a malignant tumor.

Sponsors & Collaborators

• Qianfoshan Hospital: lead

Related Publications (3)

• Greenberg RL, Guzick AG, Schneider SC, Weinzimmer SA, Kook M, Perozo Garcia AB, Storch EA. Depressive Symptoms in Autistic Youth with Anxiety Disorders. J Dev Behav Pediatr. 2023 Dec 1;44(9):e597-e603. doi: 10.1097/DBP.0000000000001223. Epub 2023 Oct 11.

  PMID: 38019467 BACKGROUND

• Brunette MF, Erlich MD, Edwards ML, Adler DA, Berlant J, Dixon L, First MB, Oslin DW, Siris SG, Talley RM. Addressing the Increasing Mental Health Distress and Mental Illness Among Young Adults in the United States. J Nerv Ment Dis. 2023 Dec 1;211(12):961-967. doi: 10.1097/NMD.0000000000001734.

  PMID: 38015186 BACKGROUND

• Wong WLE, Arathimos R, Lewis CM, Young AH, Dawe GS. Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach. PLoS One. 2023 Nov 15;18(11):e0294045. doi: 10.1371/journal.pone.0294045. eCollection 2023.

  PMID: 37967073 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Form of biological specimen storage: venous blood was collected on an empty stomach, 5 ml was placed in a blood collection tube containing procoagulant and 5 ml was placed in a blood collection tube containing anticoagulant. Blood and other non-tissue samples are stored in a refrigerator at -86°C. The identification of the stored samples is unique and does not contain any donor identification information; the unique code is automatically and randomly generated by the sample bank management system and consists of 18 digits.

MeSH Terms

Conditions

Genetic Predisposition to Disease; Inflammation

Condition Hierarchy (Ancestors)

Disease Susceptibility; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Guang Zhang, Dr

  Qianfoshan Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Wenqi Hu, MPH

CONTACT

15098719908; huwenqi_epi@163.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Vice President

Study Record Dates

• First Submitted: December 11, 2023
• First Posted: January 5, 2024
• Study Start: January 1, 2024
• Primary Completion: March 31, 2024
• Study Completion: December 31, 2024
• Last Updated: January 5, 2024

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will not share