Hearing and Cognition in Aging Adults

NCT06183450 | Not Yet Recruiting

• 2 other identifiers: RC31/22/02522023-A01415-40
• Study Type: observational
• Target: 262
• Locations: 1 country
• Sites: 1

Brief Summary

This cohort study is expected to provide valuable insights into the complex interplay between auditory and cognitive functions and how they change over time. The results of this study will have important implications for the prevention, diagnosis, and treatment of age-related hearing and cognitive disorders

Conditions

Presbycusis

Keywords

presbycusis; aging; cognitive decline; speech in noise; sound localisation; hearing loss

Outcome Measures

Primary Outcomes (1)

• Pure-ton audiometry

  Pure-tone audiometry will be evaluated by collecting the threshold in air and bone conduction for both ears on each frequency tested (125-250-500-1000-2000-4000 and 8000 Hz), as well as the average hearing loss (MAP ) on all five frequencies.

  5 years

Study Arms (1)

hearing subject

Adult normal hearing subjects, evaluated annually for 5 years,

Diagnostic Test: auditory level; Diagnostic Test: cognitive level; Diagnostic Test: quality of life level

Interventions

auditory level DIAGNOSTIC_TEST

* Evaluation of auditory thresholds through audiometric tests. * Evaluation of speech comprehension in noise through a vocal audiometry test in noise (FraMatrix). * Evaluation of spatial auditory behavior and spatial precision using a spatial discrimination test (Minimum Audible Angle) and a static sound localization test in virtual reality.

hearing subject

cognitive level DIAGNOSTIC_TEST

* Evaluation of attention and short-term memory functions with verbal and non-verbal tasks: Digit Span Test and Reading Span Test. * Evaluation of inhibition capacities using the Stroop Test. * Evaluation of executive functions, visual attention, reasoning, and mental arithmetic using the Raven's Matrix test.

hearing subject

quality of life level DIAGNOSTIC_TEST

\- Evaluation of quality of live level via Speech, Spatial and Qualities of Hearing Scale (SSQ-12) and EuroQol-5D questionnaires.

hearing subject

Eligibility Criteria

• Age: 45 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Adult normal hearing subjects aged between 45 and 50 years old.

You may qualify if:

• Normal hearing (Pure Tone Audiometry \< or = 20 dB)
• Residency in one of the three neighborhoods :
• Affiliation with a social security system

You may not qualify if:

• Individuals under guardianship, trusteeship or curators
• History of neurological pathologies
• Taking of psychotropic medication.

Sponsors & Collaborators

• University Hospital, Toulouse: lead

Study Sites (1)

Ecole d'audioprothèse

Cahors, France

Location

MeSH Terms

Conditions

Presbycusis; Cognitive Dysfunction; Hearing Loss

Condition Hierarchy (Ancestors)

Hearing Loss, Sensorineural; Hearing Disorders; Ear Diseases; Otorhinolaryngologic Diseases; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Mathieu Marx, Pr

  University Hospital, Toulouse

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mathieu Marx, Pr

CONTACT

05 61 77 77 04; marx.m@chu-toulouse.fr

Mariam ALZAHER, Dr

CONTACT

mariam.alzaher@cnrs.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 6, 2023
• First Posted: December 27, 2023
• Study Start: January 1, 2024
• Primary Completion (Estimated): January 1, 2033
• Study Completion (Estimated): January 1, 2033
• Last Updated: December 27, 2023

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)