Age-related Hearing Loss and Lexical Disorders

NCT03638323 | Completed Results

• 1 other identifier: 2018/P08/256
• Study Type: observational
• Target: 46
• Locations: 1 country
• Sites: 1

Brief Summary

In France, Alzheimer's disease accounts for 70 to 80% of the causes of neurocognitive disorders, i.e. 600,000 to 800,000 patients. It is a neurodegenerative pathology that causes evolutionary cognitive dysfunction, mainly affecting memory functions. The inability to name familiar objects (lack of the word) is one of the most commonly noted symptoms at an early stage of the disease. Presbyacusis, or age-related hearing loss, is the most common sensory deficit in the elderly which is manifested socially by a progressive discomfort of verbal communication. Presbyacusis remains underdiagnosed and undertreated: 2/3 of the patients are not using hearing aid. In recent years, a link between neurocognitive disorders and hearing loss has been shown by investigating general cognition. In this study, the investigators are investigating lexical disorders.

Conditions

Lexical Syntactic Disorder; Alzheimer Disease; Presbycusis

Outcome Measures

Primary Outcomes (1)

• Link Between Lack of Word and Presbycusis

  The Batterie Informatisée du Manque du Mot (BIMM) is a computerized assessment instrument for denominational disorders. It provides information on level of lexical impairment, type of error (phonological, semantic, visual perceptual) and response time. It comprises two tests: denomination of nouns (42 items, score range from 0 to 42) and of verbs (28 items, score range from 0 to 28). The results are presented in a report including scores, description of qualitative errors, and results per item. A global score of less than 40 indicates a lack of words. The score range is between 0 and 70. The hearing questionnaire consists in 14 questions about concrete situations and a direct question about what the patient thinks of his hearing. Answers are quoted 0, 2 or 4 points. An overall score greater than 14 indicates presbycusis.

  at inclusion

Secondary Outcomes (8)

• Association Between Age and Lack of Word

  at inclusion

• Association Between Gender and Lack of Word

  at inclusion

• Association Between Study Level and Lack of Word

  at inclusion

• Association Between Accommodation Type and Lack of Word

  at inclusion

• Association Between Laterality and Lack of Word

  at inclusion

Study Arms (1)

LOOP group

Speech therapy consultation for patients with Alzheimer's disease

Other: Speech therapy

Interventions

Speech therapy OTHER

During a 1-hour speech-language consultation, a lack of word evaluation will be conducted and patient will answer a Hearing Difficulty Questionnaire

LOOP group

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Series of patients from the Care Center for the Elderly (geriatric day hospital, long-term care units, follow-up care units and rehabilitation)

You may qualify if:

• \> 65 years old
• French mother tongue
• Good vision with or without correction
• Alzheimer's or related disease (15 \<Mini-Mental State Examination\<25)
• Affiliate or beneficiary of a social security
• Informed consent

You may not qualify if:

• Cognitive disorders related to another pathology (cerebrovascular accident, head trauma, epilepsy ...)
• Protected patient (under guardianship) or person deprived of liberty by judicial or administrative decision

Sponsors & Collaborators

• Groupe Hospitalier de la Rochelle Ré Aunis: lead

Study Sites (1)

Groupe Hospitalier de la Rochelle Ré Aunis

La Rochelle, France

Location

Related Publications (1)

• Camille Roche, Aude Bournazel, Caroline Allix-Béguec, Marie-Laure Pinon-Vignaud. Étude pilote des liens entre la presbyacousie et les troubles lexicaux chez les patients atteints de maladie d'Alzheimer ou maladie apparentée. Audiology Direct. September 2020. DOI: 10.1051/audiodir/202004002

  RESULT

MeSH Terms

Conditions

Alzheimer Disease; Presbycusis

Interventions

Speech Therapy

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders; Hearing Loss, Sensorineural; Hearing Loss; Hearing Disorders; Ear Diseases; Otorhinolaryngologic Diseases; Sensation Disorders; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Rehabilitation of Speech and Language Disorders; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics

Results Point of Contact

• Title: Marie-Laure Vignaud, neuropsychologist
• Organization: Groupe Hospitalier de la Rochelle Ré Aunis

marie-laure.vignaud@ght-atlantique17.fr

+33 (0)5 46 45 63 70

Study Officials

• Marie-Laure Vignaud, Ph.D.

  Groupe Hospitalier de la Rochelle Ré Aunis

  STUDY DIRECTOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 14, 2018
• First Posted: August 20, 2018
• Study Start: August 27, 2018
• Primary Completion: January 31, 2019
• Study Completion: January 31, 2019
• Last Updated: March 19, 2026
• Results First Posted: September 11, 2019

Record last verified: 2026-03

Locations

FR (1)