Effectiveness of Distal and Proximal Muscle Fatigue for Healthy Young Adults

NCT06181071 | Completed

• 1 other identifier: SaglikBilimleri22-114
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

This is a study aiming to investigate the effects of acute muscle fatigue on muscle properties, balance and foot plantar pressure in healthy young adults (having no chronic diseases or orthopaedic diseases and physically active). This study also aims to compare the effects of foot muscle fatigue and hip muscle fatigue on balance and foot plantar pressure. The exercises for ankle muscle fatigue are heel rise with bending your knee and heel raise without bending your knees. The exercise for hip muscle fatigue is a single-leg squat. Before and after completing these all exercises, the balance is evaluated with an isokinetic balance device, the foot plantar pressure is evaluated with a pedobarography device and finally, the muscle properties are evaluated with a myotonPro device. All assessment devices are non-invasive.

Conditions

Healthy; Young Adult; Fatigue

Keywords

muscular fatigue; balance; elasticity; muscle tonus; foot plantar pressure

Outcome Measures

Primary Outcomes (2)

• Myotonometric Assesment

  Myotonometeric assessment is a non-invasive and novel method used to characterize the viscoelastic and biomechanical properties of muscles. The MyotonPro (Myoton Ltd, Myoton AS, Estonia) is an objective assessment tool that has been validated for inter-rater and intra-rater reliability, enabling the evaluation of mechanical and viscoelastic properties such as muscle tone, stiffness, and elasticity. The MyotonPro device is positioned perpendicular to the skin surface when the muscles are in a relaxed position. The device's probe applies an initial pressure of approximately 0.18 N to the skin surface, compressing the underlying tissue. Subsequently, a mechanical force of 0.4 N is applied for 15 ms to the compressed tissue beneath the skin.

  Day 1 and Day 8

• Isokinetic Balance Assesment

  The TecnoBody Prokin PK 252 device, which is one of the objective methods used for the assessment of static and dynamic balance, allows the acquisition of numerical data at the end of the evaluation. Equipped with an isokinetic balance system, this device consists of a screen monitor and a sloped platform on which the individuals being evaluated stand. This platform has air pistons that provide a 15-degree tilt in all directions. These air pistons come into play, especially during the assessment of dynamic balance. The settings of the platform can be adjusted according to the evaluator's decision, thanks to the servo motors associated with the device.

  Day 1 and Day 8

Secondary Outcomes (1)

• Foot Plantar Pressure Distribution Assesment

  Day 1 and Day 8

Study Arms (2)

Distal Fatigue of The Lower Extremity

OTHER

Distal muscle fatigue of the lower extremity involves the plantar and dorsiflexor muscles of the ankle.

Other: Distal Muscle Fatigue Protocol; Other: Proximal Muscle Fatigue Protocol

Proximal Fatigue of The Lower Extremity

OTHER

Proximal muscle fatigue of the lower extremity involves hip flexor and extansor muscles.

Other: Distal Muscle Fatigue Protocol; Other: Proximal Muscle Fatigue Protocol

Interventions

Distal Muscle Fatigue Protocol OTHER

Initially, sociodemographic data, muscle viscoelastic properties, foot plantar pressure, and static and dynamic balance are assessed. Additionally, the strengths of the plantar flexor and dorsiflexor muscles are evaluated. After these assessments, the heel raise exercise will be implemented in this protocol. Firstly, dominant leg, the heel raise exercise will be performed for 3 sets with the knees in full extension until the individual reaches fatigue. Subsequently, the heel raise exercise will be conducted for another 3 sets with the knee in flexion until the individual reaches fatigue. Following these exercises, Then, the strengths of the hip flexor and extensor muscles will be re-evaluated. If the individual reports a value of 7 or higher on the modified Borg scale, the viscoelastic properties of the muscles, foot plantar pressure, and static and dynamic balance will be reassessed when a 50% decrease in the initial strength is detected.

Distal Fatigue of The Lower Extremity; Proximal Fatigue of The Lower Extremity

Proximal Muscle Fatigue Protocol OTHER

One week after the application of the distal muscle fatigue protocol, the same individuals will undergo the proximal fatigue protocol. In this protocol, individuals will perform, dominant leg, a single-leg squat exercise targeting the fatigue of the hip flexor and extensor muscles. Prior to this exercise, the viscoelastic properties of the muscles, foot plantar pressure, static and dynamic balances, as well as the strengths of the hip flexor and extensor muscles will be assessed. Then, individuals will perform the single-leg squat exercise, 3 sets. When the individual indicates fatigue, the set will conclude, allowing a 30-second rest between sets. Then, the strengths of the hip flexor and extensor muscles will be re-evaluated. If the individual reports a value of 7 or higher on the modified Borg scale, the viscoelastic properties of the muscles, foot plantar pressure, and static and dynamic balance will be reassessed when a 50% decrease in the initial strength is detected.

Distal Fatigue of The Lower Extremity; Proximal Fatigue of The Lower Extremity

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• To be a healthy individual in the age range of 18-35,
• To be willing to participate in the study,
• To have a minimal active or highly active score on the International Physical Activity Questionnaire (Short Form),
• To have a body mass index (BMI) of 24.9 kg/m² or lower.

You may not qualify if:

• Having a history of injury and/or surgical operation related to the lower extremity,
• Having limited mobility in the lower extremity,
• Having any deformity related to the lower extremity,
• Having cardiovascular, vestibular, neurological, orthopedic, or skin-related diseases,
• Having any chronic disease that may affect balance,
• Having any acute/chronic musculoskeletal pain or systemic pain,
• Not to have given consent to participate in the study or to wish to withdraw from the study.

Sponsors & Collaborators

• Saglik Bilimleri Universitesi: lead

Study Sites (1)

University of Health Sciences, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation Laboratory

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Fatigue

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Gulenay Yildirim

  Saglik Bilimleri Universitesi

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant

Study Record Dates

• First Submitted: December 11, 2023
• First Posted: December 26, 2023
• Study Start: December 1, 2023
• Primary Completion: January 10, 2024
• Study Completion: January 18, 2024
• Last Updated: August 22, 2025

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)