Throid Dysfunction in Liver Failure and Its Eddects Upon Outcome

NCT06179368 | Unknown

• 1 other identifier: IRB121223
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Liver plays an important role in the metabolism of thyroid hormones, as it is the most important organ in the peripheral conversion of tetraiodothyronine (T4) to triiodothyronine (T3) by Type 1 deiodinase.

Conditions

Hepatic Encephalopathy; Hepatic Impairment; Hypothyroidism; Hepatic Failure

Keywords

Hepatic Failure; Hypothyroidism

Outcome Measures

Primary Outcomes (1)

• short termoutcome

  mortality during hospitalstay

  (0 to 30 days)

Secondary Outcomes (1)

• complications

  (0 to 30 days)

Study Arms (2)

Hypothroid group

throid fuction will be evaluated on admission of hepatic failure patients, and the hypothroid patients will be enroled in this group.

Diagnostic Test: hypothroidism

Euthroid group

throid fuction will be evaluated on admission of hepatic failure patients, and the euothroid patients will be enroled in this group.

Diagnostic Test: euothyroid

Interventions

hypothroidism DIAGNOSTIC_TEST

throid fuction will be evaluated on admission of hepatic failure patients, and the hypothyroid patients will be enroled in this group.

Hypothroid group

euothyroid DIAGNOSTIC_TEST

throid fuction will be evaluated on admission of hepatic failure patients, and the euothyroid patients will be enroled in this group.

Euthroid group

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

all hepatic failutre patients who will be admitted to ICU will be enrolled, and throid function will be assessed. Groupingwil be done based upon throid function

You may qualify if:

• \- hepatic fauiure patients

You may not qualify if:

• hypethyroid patients

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Emad Zarief Kamel Said

Asyut, 71111, Egypt

RECRUITING

Related Publications (2)

• Punekar P, Sharma AK, Jain A. A Study of Thyroid Dysfunction in Cirrhosis of Liver and Correlation with Severity of Liver Disease. Indian J Endocrinol Metab. 2018 Sep-Oct;22(5):645-650. doi: 10.4103/ijem.IJEM_25_18.

  PMID: 30294575 BACKGROUND

• McCormick PA. Sherlock's Diseases of the Liver and Biliary System Textbook. Hepatic Cirrhosis. In: Dooley JS, Lok AS, Burroughs AK, Heathcote EJ, editors. 12th ed. Ch. 7. UK: Wiley-Blackwell, A John Wiley and Sons, Ltd; 2011. pp. 103-8.

  BACKGROUND

MeSH Terms

Conditions

Hepatic Encephalopathy; Hypothyroidism; Liver Failure

Condition Hierarchy (Ancestors)

Hepatic Insufficiency; Liver Diseases; Digestive System Diseases; Brain Diseases, Metabolic; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Thyroid Diseases; Endocrine System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: December 12, 2023
• First Posted: December 21, 2023
• Study Start: January 1, 2024
• Primary Completion: April 1, 2024
• Study Completion: May 1, 2024
• Last Updated: January 16, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)