Periodization Resistance Training on Quality of Life in Females With Hypothyroidism

NCT06757712 | Recruiting

• 1 other identifier: P.T.REC/012/005442
• Study Type: interventional
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

This study will be conducted to compare between the effect of nonlinear and linear periodized training on quality of life in females with hypothyroidism.

Conditions

Hypothyroidism

Outcome Measures

Primary Outcomes (3)

• Serum thyroid stimulating hormone (TSH) level

  It will be measured by ELISA kits. This kit is an Enzyme Linked Immunosorbent Assay (ELISA). (Precheck bio, inc, @ EIA KIT, USA).

  12 weeks

• FreeT4 (thyroxine) level

  It will be measured by ELISA kits. This kit is an Enzyme Linked Immunosorbent Assay (ELISA). (Precheck bio, inc, @ EIA KIT, USA).

  12 weeks

• Health related Quality of life questionnaire

  The Health related Quality of life will be assessed using short form 12 (SF-12), which uses only 12 questions to measure functional health and well being from the patient's perspective. Scores range from 0 to 100, with higher scores indicating better physical and mental health functioning.

  12 weeks

Secondary Outcomes (3)

• Triglyceride-glucose (TyG) index

  12 weeks

• Hand grip strength

  12 weeks

• 9-item Fatigue Severity Scale (FSS)

  12 weeks

Study Arms (3)

non linear periodization exercise + medical treatment

EXPERIMENTAL

It will consist of 25 females, who will receive non linear periodization exercise in addition to their medical treatment.

Other: non linear periodization exercise; Drug: medical treatment

linear periodization exercise + medical treatment

EXPERIMENTAL

It will consist of 25 females, who will receive linear periodization exercise in addition to their medical treatment.

Other: linear periodization exercise; Drug: medical treatment

medical treatment

ACTIVE COMPARATOR

It will consist of 25 females, who will receive their medical treatment only.

Drug: medical treatment

Interventions

non linear periodization exercise OTHER

The non-linear periodized resistance training program follows a 12-week schedule with varying intensity levels across three training days per week. The intensity fluctuates between very light (VL), light (L), moderate (M), heavy (H), and very heavy (VH) workouts, distributed strategically throughout the week. Each training day implements different intensity levels, and an active rest day follows any workout session.

non linear periodization exercise + medical treatment

linear periodization exercise OTHER

The linear periodization exercise program spans 12 weeks with systematically varied training parameters. During weeks 1-2, participants perform 3 sets of 10 repetitions, followed by 3 sets of 8 repetitions in weeks 3-4. The program progresses to 4 sets of 6 repetitions in weeks 5-6, then 3 sets of 6 repetitions during weeks 7-8. The final phases consist of 4 sets of 4 repetitions in weeks 9-10, concluding with 3 sets of 4 repetitions in weeks 11-12. Training loads advance through autoregulatory progression, where participants progress at their individual pace under supervision. While sets and repetitions remain fixed within each phase, load progression is determined by performance in the final set of each exercise, ensuring safe and effective advancement.

linear periodization exercise + medical treatment

medical treatment DRUG

The medical treatment will be received for 12 weeks.

linear periodization exercise + medical treatment; medical treatment; non linear periodization exercise + medical treatment

Eligibility Criteria

• Age: 35 Years - 45 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Be controlled hypothyroidism (TSH level within 0.5 - 4.5 mU/L)
• Be ranged from 35 to 45 years
• Female patients
• Body Mass Index 30-34.9 kg/m2 .
• triglyceride-glucose (TyG) index \> 4.5

You may not qualify if:

• history of pulmonary disease
• Patients with uncontrolled coronary or cerebrovascular disease
• Those who underwent musculoskeletal surgery within the previous year
• Recent history of lower and upper limb fracture , hip and shoulder dislocation.
• Cognitive impaired patients
• Patients with history of epilepsy
• Patients who participating in any other exercise program

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Suez University

Suez, Egypt

RECRUITING

MeSH Terms

Conditions

Hypothyroidism

Condition Hierarchy (Ancestors)

Thyroid Diseases; Endocrine System Diseases

Study Officials

• Nesreen Gharib Mohamed Elnahas, PhD

  Professor, Cairo university

  STUDY CHAIR

Central Study Contacts

Mona Mahmoud Mohamed Abd Elhady, M.Sc

CONTACT

01127744248; dmonamahmoud925@gmail.com

Salma Ibrahim Al Ghitany, PhD

CONTACT

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 27, 2024
• First Posted: January 3, 2025
• Study Start: January 1, 2025
• Primary Completion: October 1, 2025
• Study Completion: October 15, 2025
• Last Updated: September 12, 2025

Record last verified: 2025-09

Locations

EG (1)