Embedded Narrative in Interactive Game Design for Improving Medication Adherence of Schizophrenia

NCT06175559 | Completed

• 1 other identifier: Sjtu0002
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This study explores the potential of an interactive narrative game to enhance medication adherence among stable schizophrenia patients. Employing participatory design methods, game's development and testing process actively involved patients and individuals closely connected to their daily lives. Artificial Intelligence-Generated Content (AIGC) facilitated swift iterations in game's visual style and content. During game therapy, patients are tasked with making decisions based on presented situations, which influence the course of the narrative.

Conditions

Medication Adherence; Mental Health Issue; Gamification; Schizophrenia and Related Disorders

Outcome Measures

Primary Outcomes (2)

• Medication Adherence

  Medication Adherence - Morisky Medication Adherence Scale-8 (MMAS-8): This scale assesses medication adherence through 8 items, providing a comprehensive evaluation of adherence.

  10 minutes

• Medication Attitude

  Medication Attitude - Drug Attitude Inventory (DAI) : This scale evaluates patients' attitudes toward medication, with higher scores indicating better attitudes.

  10 minutes

Secondary Outcomes (6)

• Game Experience

  10 minutes

• Anxiety

  10 minutes

• Depression

  10 minutes

• Patients' Quality of Life

  10 minutes

• Social Functioning

  10 minutes

Study Arms (1)

Healing Town: Embedded Narrative in Interactive Game Design

EXPERIMENTAL

The game-based medication intervention game "Wanping Town" in this study employed a multidisciplinary participatory design approach rooted in narrative theory and behavioral psychology models. The game consists of two perspectives: narrative decision stories and cognitive games. The investigators initially employed participatory design methods to determine the plot and elements within the game, then embedded the conclusions into the therapeutic elements of the game.

Combination Product: Healing Town: Embedded Narrative in Interactive Game (Psycho-education Tool) Design

Interventions

Healing Town: Embedded Narrative in Interactive Game (Psycho-education Tool) Design COMBINATION_PRODUCT

The narrative-based medication intervention game "Healing Town" in this study employed a multidisciplinary participatory design approach rooted in narrative theory and behavioral psychology models. The game consists of two perspectives: narrative decision stories and cognitive games. The investigators initially employed participatory design methods to determine the plot and elements within the game, then embedded the conclusions into the therapeutic elements of the game

Healing Town: Embedded Narrative in Interactive Game Design

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Stable Phase Schizophrenia
• on long-term medication
• medication adherence was problematic

You may not qualify if:

• Serious Schizophrenia
• Lack of basic cognitive abilities

Sponsors & Collaborators

• Zhu Dian: lead

Study Sites (1)

Shanghai Jiao Tong University

Shanghai, Shanghai Municipality, 200240, China

Location

Related Publications (1)

• Liu Z, Zhu D, Zhang Z, Liu Y, Yang H, Chang F, Zhang W, Cai J. Effects of a narrative-based psychoeducational intervention on medication adherence in individuals with schizophrenia: a multicentre, parallel-group randomised controlled trial. EClinicalMedicine. 2025 Sep 4;88:103483. doi: 10.1016/j.eclinm.2025.103483. eCollection 2025 Oct.

  PMID: 40979217 DERIVED

MeSH Terms

Conditions

Schizophrenia; Medication Adherence

Interventions

Research Design

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Patient Compliance; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior; Behavior

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Study Officials

• Zhao Liu, Prof

  Shanghai Jiao Tong University School of Medicine

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 8, 2023
• First Posted: December 19, 2023
• Study Start: September 1, 2023
• Primary Completion: August 1, 2024
• Study Completion: September 1, 2025
• Last Updated: April 30, 2026

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: After the article is accepted
• Access Criteria: zhudian@sjtu.edu.cn

Locations

CN (1)