NCT06173843

Brief Summary

This study aims to understand the effect of occupational exposures, including PFAS exposures, among firefighters.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,000

participants targeted

Target at P75+ for all trials

Timeline
45mo left

Started Dec 2023

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress40%
Dec 2023Dec 2029

Study Start

First participant enrolled

December 6, 2023

Completed
1 day until next milestone

First Submitted

Initial submission to the registry

December 7, 2023

Completed
11 days until next milestone

First Posted

Study publicly available on registry

December 18, 2023

Completed
5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2028

Expected
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2029

Last Updated

November 14, 2024

Status Verified

November 1, 2024

Enrollment Period

5.1 years

First QC Date

December 7, 2023

Last Update Submit

November 12, 2024

Conditions

Cancer

Keywords

CancerOccupational exposure

Outcome Measures

Primary Outcomes (1)

  • Exposures associated with elevated PFAS

    5 years

Secondary Outcomes (1)

  • Cancer rates

    5 years

Study Arms (2)

Firefighters

Other: PFAS / heavy metal testing, exposures

Non-Firefighters

Other: PFAS / heavy metal testing, exposures

Interventions

PFAS / heavy metal testing, exposuresOTHER

PFAS / heavy metal concentrations, exposure survey

FirefightersNon-Firefighters

Eligibility Criteria

Age18 Years+
Sexall(Gender-based eligibility)
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Actively working or retired firefighters of any adult age, any gender and any demographic group are eligible, with no limitations regarding general health status other than those specified in the protocol Eligibility Criteria.

You may qualify if:

  • years of age or older; any gender
  • Currently (or previously) employed as a firefighter, full-time or part-time, participating in Vincere's First Responder Cancer Screening Program
  • Willing to provide a blood, urine, and/or tissue sample
  • Able to provide informed consent to participate in the study
  • (A small group of non-firefighters will be enrolled to act as a comparison group)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Vincere Cancer Center

Scottsdale, Arizona, 85260, United States

RECRUITING

MeSH Terms

Conditions

Neoplasms

Interventions

phosphoribosylformylglycinamidine synthetase

Central Study Contacts

Christine Lau, MD

CONTACT

480-306-5390drlau@vincerecancer.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 7, 2023

First Posted

December 18, 2023

Study Start

December 6, 2023

Primary Completion (Estimated)

December 31, 2028

Study Completion (Estimated)

December 31, 2029

Last Updated

November 14, 2024

Record last verified: 2024-11

Data Sharing

IPD Sharing
Will not share

Locations

US(1)