NCT05780957

Brief Summary

This study is an an observational prospective cohort research study to explore the performance of new blood and urine tests for the early detection of cancer among firefighters.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,000

participants targeted

Target at P75+ for all trials

Timeline
57mo left

Started Mar 2023

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress40%
Mar 2023Dec 2030

First Submitted

Initial submission to the registry

March 10, 2023

Completed
11 days until next milestone

Study Start

First participant enrolled

March 21, 2023

Completed
2 days until next milestone

First Posted

Study publicly available on registry

March 23, 2023

Completed
3.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2030

Last Updated

November 5, 2025

Status Verified

November 1, 2025

Enrollment Period

3.8 years

First QC Date

March 10, 2023

Last Update Submit

November 3, 2025

Conditions

Cancer

Keywords

CancerMulti-Cancer Early DetectionMCED

Outcome Measures

Primary Outcomes (2)

  • Sensitivity, specificity, positive and negative predictive performance values (PPV and NPV) to detect cancer using Elypta's MCED test, as measured in plasma, in urine, and in plasma and urine combined

    Up to 7 years

  • Sensitivity, specificity, positive and negative predictive performance values to detect cancer using Proteotype's MCED test, as measured in plasma.

    Up to 2030

Study Arms (1)

Firefighters who receive multi-cancer early detection (MCED) test

Other: MCED

Interventions

MCEDOTHER

multi-cancer early detection (MCED) test

Firefighters who receive multi-cancer early detection (MCED) test

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Actively working firefighters of any adult age, any gender and any demographic group are eligible, as well as no limitations regarding general health status other than those specified in the protocol Eligibility Criteria.

You may qualify if:

  • years of age or older
  • Currently employed as a firefighter, full-time or part-time
  • Taking part in Vincere's First Responder Cancer Screening Program
  • Able to donate blood and urine sample
  • Able to provide informed consent to participate in the study

You may not qualify if:

  • Deemed medically unfit for sample donation
  • Personal history of cancer in the last 5 years (with the exception of non-melanoma skin cancer)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Vincere Cancer Center

Scottsdale, Arizona, 85260, United States

RECRUITING

MeSH Terms

Conditions

Neoplasms

Study Officials

  • Vershalee Shukla, MD

    Vincere Cancer Center

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Christine Lau, MD

CONTACT

480-306-5390drlau@vincerecancer.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 10, 2023

First Posted

March 23, 2023

Study Start

March 21, 2023

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2030

Last Updated

November 5, 2025

Record last verified: 2025-11

Locations

US(1)