Effects of Eccentric Exercise Training in Patients With COPD

NCT06168266 | Recruiting

• 1 other identifier: FJUH111246
• Study Type: interventional
• Target: 170
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to design eccentric exercise strategies for COPD patients to comprehensively improve their cardiopulmonary/muscular fitness, immune and hemorheological functions, and quality of life, thereby improving the prognosis of their disease.

Conditions

COPD

Keywords

COPD; Eccentric Exercise Training; Lymphocytes; Mitochondria; Erythrocytes; Rheology

Outcome Measures

Primary Outcomes (1)

• cardiopulmonary oxygen consumption

  to observe the maximum exercise performance

  12 weeks

Study Arms (2)

Control group

ACTIVE COMPARATOR

Undergoing conventional treatment

Other: conventional group

Intervention Group: eccentric cycling exercise

EXPERIMENTAL

Received eccentric cycling exercise

Device: Eccentric bike

Interventions

Eccentric bike DEVICE

Received eccentric cycling exercise

Intervention Group: eccentric cycling exercise

conventional group OTHER

Received conventional treatment

Control group

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Having undergone pulmonary rehabilitation for more than 3 months
• Sign the written informed consent form
• FEV1/FVC \< 0.70
• Approval for exercise training granted by a specialist physician's assessment
• Specialist physician's approval for exercise training

You may not qualify if:

• Existing of tracheostomy
• Those who use oxygen therapy or ventilator at home
• Severe heart failure (NYHA III-IV)
• Neuromuscular disease
• Acute exacerbation within the past three months
• Those who are unable to cooperate with the cardiopulmonary exercise test
• Taking anticoagulant medications
• Other conditions restricting exercise for over a year
• Recent or planned significant cardiovascular surgery or intervention
• Current or planned pregnancy within the next year
• Planned heart transplant within the next six months
• Heart failure due to uncorrectable valvular heart disease, congenital heart disease or obstructive cardiomyopathy
• Inadequate ICD settings for exercise heart rate
• Other exercise contraindications: unstable angina, uncontrolled blood pressure, orthostatic hypotension with symptoms, severe aortic stenosis, acute discomfort or fever, uncontrolled arrhythmias, uncompensated heart failure, acute pericarditis or myocarditis, recent thrombosis or thrombophlebitis, resting ST-segment deviation, uncontrolled diabetes, etc.

Sponsors & Collaborators

• Fu Jen Catholic University: lead

Study Sites (1)

Fu Jen Catholic University Hospital, Fu Jen Catholic University

New Taipei City, 24352, Taiwan

RECRUITING

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Ke-Yun Chao, PhD

  Fu Jen Catholic University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ke-Yun Chao, PhD

CONTACT

+886905301879; C00152@mail.fjuh.fju.edu.tw

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Group leader of Respiratory Therapists

Study Record Dates

• First Submitted: December 5, 2023
• First Posted: December 13, 2023
• Study Start: December 13, 2023
• Primary Completion (Estimated): October 30, 2027
• Study Completion (Estimated): December 30, 2027
• Last Updated: February 12, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)