Standardising and Simplifying the Global Leadership Initiative on Malnutrition (GLIM) for Its More General Application

NCT06164925 | Recruiting

• 1 other identifier: 23092
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This observational study of aims to test whether and how the results of GLIM change when using different approaches and methods to carry out its components.

Conditions

Malnutrition

Keywords

GLIM criteria; GLIM; nutrition assessment; nutrition screening; muscle mass

Outcome Measures

Primary Outcomes (4)

• Subjective Global Assessment (SGA) defined malnutrition

  Subjective Global Assessment (SGA) can be considered a method that is close to a "gold standard" for malnutrition assessment. Therefore, the study will analyse how different approaches to screening and muscle mass measurement affect the performance of GLIM in detecting Subjective Global Assessment (SGA) defined malnutrition.

  baseline, pre-intervention/procedure/surgery

• One-year mortality

  One year after the data collection, we will look at the patient records to collect the 1-year mortality data. This will give information about whether and how different approaches to components of GLIM affect its ability to predict one-year mortality.

  through study completion, an average of 1 year

• Computed tomography (CT) defined muscle mass

  One of the GLIM criteria is "reduced muscle mass", and this study will investigate how muscle mass measured with simpler methods compares against muscle mass measured with CT.

  baseline, pre-intervention/procedure/surgery

• DEXA defined muscle mass

  One of the GLIM criteria is "reduced muscle mass", and this study will investigate how muscle mass measured with simpler methods compares against muscle mass measured with DEXA.

  baseline, pre-intervention/procedure/surgery

Secondary Outcomes (1)

• Bioelectrical impedance (BIA) defined muscle mass

  baseline, pre-intervention/procedure/surgery

Study Arms (1)

Inpatients of the Tartu University Hospital

Inclusion Criteria: Age of 18+ years, able and willing to sign the consent form, inpatients of the Tartu University Hospital, admitted within 72 hours before enrolment. Exclusion Criteria: Age of \<18 years, inability or refusal to sign the consent form, pregnant or lactating women, more than 72 hours passed since admission, patients isolating with an infection.

Diagnostic Test: Nutrition screening and assessment

Interventions

Nutrition screening and assessment DIAGNOSTIC_TEST

The patient is interviewed for changes in body weight in the last six months and food intake in the last two weeks. The investigator evaluates the patient's diet, symptoms related to their nutritional status, and functional capacity according to the Subjective Global Assessment (SGA). The SGA tool itself is completed by the researcher. Height and weight of the patient are measured, if not yet recorded, and BMI is calculated. The patient's muscle mass is measured using mid-upper arm circumference (MUAC), calf circumference (CC) and bioelectrical impedance (BIA), and their muscle function assessed using hand grip strength.

Inpatients of the Tartu University Hospital

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Inpatients of day patients admitted to the Tartu University Hospital.

You may qualify if:

• Age of 18+ years
• Able and willing to sign the consent form
• Inpatients of the Tartu University Hospital
• Admitted within 72 hours before enrolment

You may not qualify if:

• Age of \<18 years
• Inability or refusal to sign the consent form
• Pregnant or lactating women
• More than 72 hours passed since admission
• Patients isolating with an infection

Sponsors & Collaborators

• University of Tartu: lead
• Tartu University Hospital: collaborator

Study Sites (1)

Tartu Ülikooli Kliinikum

Tartu, Tartu, 50406, Estonia

RECRUITING

MeSH Terms

Conditions

Malnutrition

Interventions

Physical Examination

Condition Hierarchy (Ancestors)

Nutrition Disorders; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Alastair Forbes, MD

  University of Tartu, Tartu University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Grete Kurik, BSc

CONTACT

+372 53436535; grete.kurik@ut.ee

Alastair Forbes, MD

CONTACT

alastair.forbes@ut.ee

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Visiting Professor

Study Record Dates

• First Submitted: November 1, 2023
• First Posted: December 11, 2023
• Study Start: December 13, 2023
• Primary Completion: March 31, 2025
• Study Completion: June 30, 2025
• Last Updated: March 28, 2025

Record last verified: 2025-02

Locations

ES (1)