NCT06155773

Brief Summary

The current study intends to evaluate the effect of cervical margin relocation with different restorative materials on three-year clinical performance of indirect Computer-Aided-Design (CAD)/ Computer-Aided-Manufacture (CAM) onlay restorations. This study is designed to test the null hypothesis that the three-year clinical performance of onlay restorations is significantly affected by cervical margin relocation with different restorative materials.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
64

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Aug 2021

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 24, 2021

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 5, 2022

Completed
1.8 years until next milestone

First Submitted

Initial submission to the registry

October 17, 2023

Completed
2 months until next milestone

First Posted

Study publicly available on registry

December 4, 2023

Completed
1.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2025

Completed
Last Updated

December 8, 2023

Status Verified

May 1, 2023

Enrollment Period

4 months

First QC Date

October 17, 2023

Last Update Submit

December 3, 2023

Conditions

Outcome Measures

Primary Outcomes (2)

  • Gingiva

    Gingival Index Scale from 0 to 3 will be used for evaluation considering that score 0 represents normal gigiva while score 3 represents severely inflamed gingiva

    three year follow up

  • Modified World Dental Federation (FDI) clinical Criteria

    1. Functional Properties of restorations: 1. Fracture of material and retention 2. Marginal adaptation 3. Radiographic examination 2. Biological Properties of restorations 1. Postoperative (hyper-sensitivity and tooth vitality 2. Recurrence of caries 3. Tooth integrity (enamel cracks, tooth fractures) 4. Periodontal Response 5. Adjacent mucosa Descriptive scale from 1 to 5. Note: 1 is clinically excellent 5 is clinically poor. Scores(1-3) are considered sufficient The overall cumulative success rate of restorations will be evaluated

    three year follow up

Study Arms (4)

Highly viscous Glass Ionomer

EXPERIMENTAL

Highly viscous glass ionomer restoration is used to elevate the subgingival cervical margin in deep class II cavities before receiving cad/cam onlay restoration

Procedure: Highly viscous glass ionomer (cervical margin relocation)

Low shrinkage Flowable Composite

EXPERIMENTAL

Low shrinkage Flowable Composite restoration is used to elevate the subgingival cervical margin in deep class II cavities before receiving cad/cam onlay restoration

Procedure: Low shrinkage Flowable Composite (cervical margin relocation)

Resin Modified Glass Ionomer

EXPERIMENTAL

Resin Modified Glass Ionomer restoration is used to elevate the subgingival cervical margin in deep class II cavities before receiving cad/cam onlay restoration

Procedure: Resin Modified Glass Ionomer (cervical margin relocation)

Bioactive Ionic Resin

EXPERIMENTAL

Bioactive Ionic Resin restoration is used to elevate the subgingival cervical margin in deep class II cavities before receiving cad/cam onlay restoration

Procedure: Bioactive Ionic Resin (cervical margin relocation)

Interventions

different dental restorative materials used to relocate deep cervical margins before receiving onlay restorations

Highly viscous Glass Ionomer

different dental restorative materials used to relocate deep cervical margins before receiving onlay restorations

Low shrinkage Flowable Composite

different dental restorative materials used to relocate deep cervical margins before receiving onlay restorations

Resin Modified Glass Ionomer

different dental restorative materials used to relocate deep cervical margins before receiving onlay restorations

Bioactive Ionic Resin

Eligibility Criteria

Age20 Years - 40 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Good general health
  • Good oral hygiene
  • Patient aging 20-40 y
  • Patients with proximal deep carious lesion
  • International caries detection and assessment system (ICDAS) 4 or 5 that diagnosed clinically and radiographically.
  • Normal response to a vitality test.

You may not qualify if:

  • poor general health
  • poor oral hygiene
  • Teeth would need direct pulp capping
  • Teeth act as abutment for fixed or removable prosthesis.
  • patients with excessive parafunctional habits
  • Patient potentially unable to be compliant to recall visits

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of dentistry , Mansoura University

Al Mansurah, Dakahlia Governorate, Egypt

Location

MeSH Terms

Conditions

Dental Caries

Condition Hierarchy (Ancestors)

Tooth DemineralizationTooth DiseasesStomatognathic Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Masking Details
double blind
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 17, 2023

First Posted

December 4, 2023

Study Start

August 24, 2021

Primary Completion

January 5, 2022

Study Completion

January 1, 2025

Last Updated

December 8, 2023

Record last verified: 2023-05

Locations