Evaluation of the Role of Poisoning Severity Score, Serum Procalcitonin and C-reactive Protein in Acute Hydrocarbon Intoxicated Cases Admitted to the Poison Control Center Ain Shams University Hospitals

NCT06151301 | Unknown

• 1 other identifier: Soh-Med-23-11-01MD
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Hydrocarbons are a primary energy source in modern society. They are present in many common household and occupational products, including motor fuels, paint thinners, cleaning agents, lotions, and industrial solvents. Unfortunately, these products are also used as agents of abuse and typically inhaled . They are derived mainly from petroleum (kerosene, gas, naphtha) or wood (turpentine, pine oil). They can be found in liquid, gas, or solid form depending on their properties. All hydrocarbons can be toxic, but aromatic (ring-shaped) and halogenated hydrocarbons typically have more severe toxicity . Toxicity occurs in various ways including through inhalation, ingestion, aspiration, and dermal exposure. Frequently, these exposures occur during attempted recreational use of the substances and sometimes for self-injurious behavior

Conditions

Acute Hydrocarbon Toxicity

Outcome Measures

Primary Outcomes (1)

• Serum procalcitonin level

  measuring the level of serum procalcitonin (reference range 0-0.05µg/L)

  1 year

Study Arms (2)

control group

20 subjects of apparently healthy persons for estimating the standard levels of the tested biomarkers.

Diagnostic Test: serum procalcitonin; Diagnostic Test: C-reactive protein

case group

60 patients divided into mild, moderate and severe toxicity according to the poisoning severity score.

Diagnostic Test: serum procalcitonin; Diagnostic Test: C-reactive protein

Interventions

serum procalcitonin DIAGNOSTIC_TEST

predicting the severity of intoxication

case group; control group

C-reactive protein DIAGNOSTIC_TEST

predicting the severity of intoxication

case group; control group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients of both sexes admitted to the Poison control center, Ain Shams university hospitals with acute hydrocarbon toxicity during the duration from December 2023 till December 2024 with a maximum number of 60 cases within 24 hours of intoxication

You may qualify if:

• Patients of both sexes admitted to the Poison control center, Ain Shams university hospitals with acute hydrocarbon toxicity during the duration from December 2023 till December 2024 with a maximum number of 60 cases within 24 hours of intoxication.

You may not qualify if:

• Patients with these criteria will be excluded:
• Cases \> 24 hours of intoxication.
• Cases with occupational exposure to hydrocarbons.
• Pregnant females.
• Any cases received any treatment before arrival to the PCC.
• Cases suffering from cardiac, respiratory, renal, hepatic or haematological disorders.
• Cases presenting with fever.
• Cases with other causes that can increase levels of CRP \& pro-calcitonin as bacterial infection, recent major trauma, major burn ,septic shock and medullary thyroid cancer.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Ain Shams university Hospital

Cairo, Egypt

Location

Central Study Contacts

Mera G Khalil, assistant lecutrer

CONTACT

01229185948; Mera_Sadek@med.sohag.edu.eg

Maha A Helal, professor

CONTACT

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant lecteurer Forensic medicine and Toxicology department sohag univerisity hospital

Study Record Dates

• First Submitted: November 21, 2023
• First Posted: November 30, 2023
• Study Start: December 1, 2023
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: November 30, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)