NLR AND CRP Useful as Cost-Effective Preliminary Prognostic Markers in ST-Elevation Myocardial Infarction

NCT06491667 | Recruiting

• 1 other identifier: Soh-med-24-0614MS
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Acute myocardial infarction (AMI) is a serious and fatal cardiovascular emergency and considered the leading cause of mortality worldwide. Atherosclerosis of coronary arteries which takes decades to manifest clinically, is the primary predisposing pathologic factor responsible for the development of coronary heart disease It has been shown that A complex immune and inflammatory pathophysiological process is thought to be crucial for in the initiation and progression of atherosclerotic plaques. Inflammation is one of the main mechanisms in the pathogenesis of atherosclerosis , Destabilization of chronic artery plaques and development of thrombosis, which are the main mechanisms in the pathophysiology of ST-segment elevation myocardial infarction (STEMI). , and the interest to the evaluation of inflammatory biomarkers in coronary artery disease (CAD) has been increasing over the last decade . Although numerous inflammatory markers, including troponin T/I, lactate dehydrogenase (LDH), and creatine kinase (CK-MB), are linked to worsened clinical outcomes in both ST elevation and non-ST elevation myocardial infarction (NSTEMI), there is an unmet need for a cost-effective biomarker for impoverished countries of the world . The neutrophil-to-lymphocyte ratio (NLR), and C-reactive protein (CRP) ; has emerged as an important inflammatory markers for cardiovascular risk stratification. And are relatively cheap inflammatory markers, can act as a bridge to mitigate the gap in assessing the cardiovascular risk and outcomes

Conditions

STEMI

Outcome Measures

Primary Outcomes (2)

• Neutrophil-lymphocyte ratio

  Explore the role of Neutrophil-lymphocyte ratio in predicting the imediate and short-term prognosis in ST-segment elevation myocardial infarction

  6 months

• C-reactive protein

  C-reactive protein in predicting the imediate and short-term prognosis in ST-segment elevation myocardial infarction

  6 months

Study Arms (2)

Elevated NLR and CRP level

Elevated NLR and CRP level

Diagnostic Test: CBC; Diagnostic Test: C-reactive protein

Normal NLR and CRP level

Elevated NLR and CRP level

Diagnostic Test: CBC; Diagnostic Test: C-reactive protein

Interventions

CBC DIAGNOSTIC_TEST

Explore the role of Neutrophil-lymphocyte ratio C-reactive protein in predicting the imediate and short-term prognosis in ST-segment elevation myocardial infarction

Elevated NLR and CRP level; Normal NLR and CRP level

C-reactive protein DIAGNOSTIC_TEST

Explore the role of Neutrophil-lymphocyte ratio C-reactive protein in predicting the imediate and short-term prognosis in ST-segment elevation myocardial infarction

Elevated NLR and CRP level; Normal NLR and CRP level

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

\- Patients with age ≥18 years of either sex, with either increase in serum cardiac biomarkers or ECG are STEMI

You may qualify if:

• Patients with age ≥18 years of either sex, with either increase in serum cardiac biomarkers or ECG are STEMI.

You may not qualify if:

• Patients presenting with NSTEMI and unstable angina
• Patients with any of these associated conditions that can affect NLR or CRP including
• Inflammatory conditions such as collagen-vascular disorders
• Acute or chronic infectious diseases.
• Auto-immune and neoplastic diseases.
• Chronic hepatic diseases.
• Renal failure.
• Thyroid disorders.
• Previous valvular heart disease.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag university hospital

Sohag, Egypt

RECRUITING

Related Publications (4)

• Gualandro DM, Caramelli B, Yu PC, Marques AC, Calderaro D. Perioperative myocardial infarction has been forgotten. J Am Coll Cardiol. 2008 May 6;51(18):1825-6; author reply 1826. doi: 10.1016/j.jacc.2008.01.035. No abstract available.

  PMID: 18452792 RESULT

• Sahoo S, Losordo DW. Exosomes and cardiac repair after myocardial infarction. Circ Res. 2014 Jan 17;114(2):333-44. doi: 10.1161/CIRCRESAHA.114.300639.

  PMID: 24436429 RESULT

• Kuklina EV, Yoon PW, Keenan NL. Prevalence of coronary heart disease risk factors and screening for high cholesterol levels among young adults, United States, 1999-2006. Ann Fam Med. 2010 Jul-Aug;8(4):327-33. doi: 10.1370/afm.1137.

  PMID: 20644187 RESULT

• Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002 Mar 5;105(9):1135-43. doi: 10.1161/hc0902.104353.

  PMID: 11877368 RESULT

MeSH Terms

Conditions

ST Elevation Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Infarction; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Magdy M Amin, Professor

  Sohag University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Albair Y Kaiser, Resident

CONTACT

01010095136; Alberyouseef@med.edu.eg

Sharaf El-DEEN Sh Abd-Allah, Professor

CONTACT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident at Internal Medicine Department Sohag University hospital

Study Record Dates

• First Submitted: July 1, 2024
• First Posted: July 9, 2024
• Study Start: July 1, 2024
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: July 9, 2024

Record last verified: 2024-07

Locations

EG (1)