Evaluation of Serum Procalcitonin in Critically Ill Patients With Suspected Sepsis

NCT03506152 | Completed

• 1 other identifier: RRG # 2013-06
• Study Type: observational
• Target: 103
• Locations: 1 country
• Sites: 1

Brief Summary

Procalcitonin is a promising marker of sepsis in critically ill patients. Procalcitonin have better diagnostic accuracy compared to White blood cell count and C - reactive protein. Investigators propose that adding Procalcitonin to the list of standard laboratory work up of critically ill patients with suspected sepsis could increase diagnostic accuracy leading to better patient care.

Conditions

Sepsis

Outcome Measures

Primary Outcomes (1)

• Diagnostic accuracy of Procalcitonin

  Diagnostic accuracy was measured in terms of sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) taking blood culture as gold standard. Furthermore, different cut offs were compared by using receiver operating characteristic curves (ROC).

  one year

Study Arms (2)

Culture positive

Diagnostic Test: Serum Procalcitonin

Culture negative

Diagnostic Test: Serum Procalcitonin

Interventions

Serum Procalcitonin DIAGNOSTIC_TEST

Seven ml of blood was drawn in gel separator tubes within 24 hours of admission in ICU for Procalcitonin determination

Culture negative; Culture positive

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with suspected sepsis were recruited

You may qualify if:

• Both male and female patients less than 70 and greater than 18 years of age
• Patients full filling the sepsis definition (American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference)
• Patients were recruited within 24 hour of ICU admission

You may not qualify if:

• Patients discharged before 24 hours
• Patients who had blood transfusion before ICU stay
• Patients with organ failure

Sponsors & Collaborators

• Aga Khan University: lead

Study Sites (1)

Sibtain Ahmed

Karachi, Sindh, 71000, Pakistan

Location

MeSH Terms

Conditions

Sepsis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant

Study Record Dates

• First Submitted: April 12, 2018
• First Posted: April 24, 2018
• Study Start: January 1, 2014
• Primary Completion: December 3, 2015
• Study Completion: December 3, 2015
• Last Updated: April 24, 2018

Record last verified: 2018-04

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)