Reverse Trigger Phenotypification and Response to Ventilatory Adjustments
RT-CHASERS
Incidence of Reverse Trigger Phenotypes and Response to Ventilatory Adjustments in Patients With ARDS
1 other identifier
observational
130
1 country
1
Brief Summary
The goal of this prospective observational study is to describe the incidence of reverse trigger (RT) in mechanically ventilated patients with diagnosis of acute respiratory distress syndrome (ARDS). The main questions it aims to answer are:
- Real incidence of RT based on continuous monitoring
- The response to mechanical ventilatiory adjustments Participants will be included as soon as neuromuscular blockers (NMB)/sedation is stopped or in case of spontaneous respiratory efforts detection, whatever happens first. Continuous monitoring will be performed by esophageal manometry until switch to a pressure support (spontaneous) mode, restart of deep sedation/neuromuscular blockers by medical indication, or death. In order to allow detection of possible RT in patients with ongoing sedation/NMB, mechanical ventilator waveforms will be screened every 1-2 hours by investigators and critical care physicians with at least 1 year of specific training in detection of dyssynchronies.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Nov 2023
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 17, 2023
CompletedFirst Submitted
Initial submission to the registry
November 19, 2023
CompletedFirst Posted
Study publicly available on registry
November 28, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2026
CompletedMarch 18, 2025
March 1, 2025
2.1 years
November 19, 2023
March 15, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Incidence of reverse trigger
Proportion of patients who developed reverse trigger
60 days
Secondary Outcomes (3)
Days of mechanical ventilation
60 days
ICU length of stay
60 days
Mortality
60 days
Other Outcomes (5)
Duration of RT
60 days
Phenotypes of RT
60 days
Intensity of breathing efforts
60 days
- +2 more other outcomes
Eligibility Criteria
Mechanically ventilated patients with acute respiratory distress syndrome.
You may qualify if:
- Diagnosis of ARDS according to the Berlin criteria and added New Global Definition 2023
- Mechanical ventilation
You may not qualify if:
- \<18 years
- Tracheostomy status
- Pneumothorax
- Tube thoracostomy with air leaks
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hospital Civil Fray Antonio Alcalde
Guadalajara, 44280, Mexico
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Miguel Ibarra Estrada, MD
Hospital Civil Fray Antonio Alcalde
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD
Study Record Dates
First Submitted
November 19, 2023
First Posted
November 28, 2023
Study Start
November 17, 2023
Primary Completion
December 31, 2025
Study Completion
February 1, 2026
Last Updated
March 18, 2025
Record last verified: 2025-03