Compensatory Cognitive Training Via Telehealth for Veterans With Alcohol Use Disorders

NCT06134128 | Completed Results

• 1 other identifier: 6208
• Study Type: interventional
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

Most individuals entering treatment for alcohol use disorders (AUDs) present with cognitive deficits across a range of cognitive domains, and these deficits frequently persist for six months or longer following remission. Cognitive deficits are associated with increased relapse rates, less treatment compliance, and poorer treatment outcomes in individuals seeking substance use treatment. Despite the high rates of cognitive impairments among adults with AUDs and their negative impact on treatment outcomes, current evidence-based treatments for AUDs do not specifically treat or address cognitive symptoms. Accessible (e.g., brief, manualized, delivered via telehealth) and effective treatments for adults with AUDs and cognitive deficits are urgently needed. The primary objective of this study is to assess the feasibility and acceptability of a manualized, 8-week, Compensatory Cognitive Training (CCT) intervention delivered via telehealth for Veterans in early remission from alcohol use disorder (AUD). The investigators hypothesize that Motivationally Enhanced Compensatory Cognitive Training for Addictions (ME-CCT-A) will be feasible and acceptable in a pilot trial of ME-CCT-A delivered via telehealth.

Conditions

Alcohol Use Disorder

Keywords

cognitive rehabilitation

Outcome Measures

Primary Outcomes (5)

• Recruitment Rate

  Number of participants included from eligible Veterans; satisfactory recruitment defined as enrolment of ≥ 50% of eligible Veterans.

  From enrollment to the end of treatment at 8 weeks

• Study Retention

  Satisfactory retention rate ≥ 75% of participants completing the intervention.

  From enrollment to the end of treatment at 8 weeks

• Feasibility of Testing Procedures

  % of participants where follow-up visit was completed.

  From enrollment to the end of treatment at 8 weeks

• Feasibility of Data Collection Methods

  % of participants with complete data sets.

  From enrollment to the end of treatment at 8 weeks

• Acceptability, by Participant Report

  Satisfactory acceptability ≥ 70% of participants score ≥ 24 on the Client Satisfaction Questionnaire (CSQ-8). CSQ-8 scores range from 8-32, with higher scores indicating greater satisfaction with the intervention.

  Measured after the 8-week intervention

Study Arms (1)

Motivationally Enhanced Compensatory Cognitive Training for Addictions Group

EXPERIMENTAL

Motivationally Enhanced Compensatory Cognitive Training for Addictions (ME-CCT-A) is a manualized group-based behavioral intervention (8 weeks, 2 hour per week) designed to improve cognitive functioning in Veterans with substance use disorders (SUDs) and cognitive complaints.

Behavioral: Motivationally Enhanced Compensatory Cognitive Training for Addictions Group

Interventions

Motivationally Enhanced Compensatory Cognitive Training for Addictions Group BEHAVIORAL

8-week manualized group-based behavioral intervention delivered via telehealth

Motivationally Enhanced Compensatory Cognitive Training for Addictions Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male and female Veterans (\>18 years) who meet criteria for AUD in early remission (\>1 month, \<12 months remission) based on the DSM-5 (American Psychiatric Association, 2013)
• Concern about a mild cognitive decline that has been identified by the Veteran or a knowledgeable informant (e.g., SUD treatment providers), and the Veteran wants treatment for their cognitive concerns
• Access to internet and webcam.

You may not qualify if:

• Intoxication or impaired capacity to understand study risks and benefits
• Major Neurocognitive Disorder, dementia, neurodegenerative disorder (e.g., Alzheimer's Disease)
• Auditory or visual impairments that would prevent ability to participate in the cognitive rehabilitation group or benefit from compensatory strategies

Sponsors & Collaborators

• Portland VA Medical Center: lead

Study Sites (1)

Portland VA Medical Center

Portland, Oregon, 97239, United States

Location

MeSH Terms

Conditions

Alcoholism

Condition Hierarchy (Ancestors)

Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Limitations and Caveats

The small sample size reduced statistical power and generalizability, although this is consistent with early stage feasibility research.

Results Point of Contact

• Title: Kate Shirley, PhD
• Organization: VA Portland Healthcare System

kate.shirley@va.gov

503-220-8262

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: FED
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 18, 2023
• First Posted: November 18, 2023
• Study Start: October 2, 2023
• Primary Completion: January 10, 2025
• Study Completion: January 10, 2025
• Last Updated: November 21, 2025
• Results First Posted: November 21, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)