NCT05674409

Brief Summary

Improving alcohol use disorder (AUD) treatment among Veterans is a national public health problem. The rate of AUD among Veterans is twice that of civilians, with up to 50% of Veterans having AUD. Family-based AUD programs are rarely undertaken in busy treatment clinics, and Veterans with problem drinking behavior or AUD are commonly excluded from couple therapies. As a result, there is a need to develop effective family AUD treatments that are both brief and highly accessible to Veterans. The purpose of this study is to evaluate a new treatment add-on called Brief Family-Involved Treatment (B-FIT), which will be delivered via telehealth among Veterans engaged in alcohol-based treatment/therapy. This study is an 12-week, Stage-II, open randomized controlled trial examining B-FIT in combination with treatment as usual (TAU), (in this case B-FIT+ Cognitive Behavioral Therapy treatment) as compared to TAU alone (CBT treatment).Veterans and their treatment companion (family member, partner, friend) will complete weekly assessments during the treatment phase in addition to 3 \& 6 month follow-up assessments, all via telehealth.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
400

participants targeted

Target at P75+ for not_applicable

Timeline
35mo left

Started Mar 2023

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress53%
Mar 2023Mar 2029

First Submitted

Initial submission to the registry

December 21, 2022

Completed
16 days until next milestone

First Posted

Study publicly available on registry

January 6, 2023

Completed
2 months until next milestone

Study Start

First participant enrolled

March 13, 2023

Completed
5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2028

Expected
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2029

Last Updated

February 5, 2026

Status Verified

February 1, 2026

Enrollment Period

5 years

First QC Date

December 21, 2022

Last Update Submit

February 3, 2026

Conditions

Outcome Measures

Primary Outcomes (6)

  • Family functioning

    Change in family functioning as measured by the Brief Family Assessment Measure-III (Brief FAM-III)

    From baseline to week 12

  • Change in Alcohol Consumption

    Change in percent days abstinent, as measured by the Alcohol Timeline Followback (TLFB)

    From baseline to week 12

  • Change in percent days drinking

    Change in percent days drinking, as measured by the Alcohol Timeline Followback (TLFB)

    From baseline to week 12

  • Change in drinks per drinking day

    Change in drinks per drinking day , as measured by the Alcohol Timeline Followback (TLFB)

    From baseline to week 12

  • Alcohol problem severity

    Change in Alcohol problem severity as measured by the Alcohol Use Disorders Identification Test (AUDIT)

    From baseline to week 12

  • Change in alcohol craving

    Change in alcohol craving as measured by the Penn Alcohol Craving Scale (PACS)

    From baseline to week 12

Study Arms (2)

Cognitive Behavioral Therapy + Brief Family-Involved Treatment

EXPERIMENTAL

Approximately half of enrolled veterans and their treatment companion will be randomly assigned to the experimental group. The identified veteran participant wil receive 12 sessions of Cognitive Behavioral Therapy for Alcohol Use Disorder (CBT for AUD). In addition, both the identified veteran and their treatment companion will receive an additional 3 sessions of Brief Family-Involved Treatment (B-FIT). B-FIT is a manualized, 3-session AUD intervention, designed to be implemented in combination with any existing alcohol treatment program.

Behavioral: Brief Family-Involved Treatment (B-FIT)Behavioral: Cognitive Behavioral Therapy for Alcohol Use Disorder (CBT for AUD)

Cognitive Behavioral Therapy

ACTIVE COMPARATOR

Approximately half of enrolled veterans and their treatment companion will be randomly assigned to the active comparator group. The identified veteran participant wil receive 12 sessions of Cognitive Behavioral Therapy for Alcohol Use Disorder (CBT for AUD).

Behavioral: Cognitive Behavioral Therapy for Alcohol Use Disorder (CBT for AUD)

Interventions

Brief Family-Involved Treatment (B-FIT) is a manualized, 3-session intervention for Alcohol Use Disorder (AUD). Designed to be implemented in combination with any existing alcohol treatment program, the goals of B-FIT are to (1) increase reinforcement for AUD treatment engagement, (2) increase positive rewards from drinking reductions, and (3) decrease drinking cues by decreasing negative communication and increasing positive communication.

Cognitive Behavioral Therapy + Brief Family-Involved Treatment

Participants will receive 12 sessions of Cognitive Behavioral Therapy for Alcohol Use Disorder (CBT for AUD).

Cognitive Behavioral TherapyCognitive Behavioral Therapy + Brief Family-Involved Treatment

Eligibility Criteria

Age21 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Participants will be 200 Veterans and a family member, plus their treatment companion, a concerned partner or friend (total N=400; 50% women veterans) aged 21 or older.
  • Meet diagnostic criteria for current moderate to severe alcohol use disorder (AUD) with 2 or more heavy drinking days (\>5 for men, \>4 for women) in the 60 days prior to enrollment
  • Have an adult family member/treatment companion who is willing to participate
  • Demonstrate cognitive functioning sufficient to provide informed consent and participate accurately (≥ 26 on the Mini-Mental Status Exam \[MMSE\])
  • Maintain a stable dose of psychotropic medications for at least 4 weeks before enrollment. Concurrent drug use disorders are acceptable provided alcohol is the Veteran's primary substance of choice. Drug use will be measured weekly and controlled for in statistical analyses if needed.
  • Are not receiving or seeking treatment for their own alcohol or drug problem
  • Report total Alcohol Use Disorders Identification Test (AUDIT) scores \<8
  • Report total Drug Abuse Screening Test (DAST-10) scores \<3.

You may not qualify if:

  • History of or current psychotic or bipolar disorder
  • Alcohol withdrawal (Clinical Institute Withdrawal Assessment for Alcohol-Revised (CIWA-Ar) score \>8)
  • Current suicidal or homicidal ideation and intent
  • Severe or unilateral violence in the past 6 months as measured by the Revised Conflict Tactics Scale (CTS2) (consistent with extant dyadic treatment literature).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Medical University of South Carolina

Charleston, South Carolina, 29401, United States

RECRUITING

MeSH Terms

Conditions

Alcoholism

Interventions

Cognitive Behavioral TherapyEthanol

Condition Hierarchy (Ancestors)

Alcohol-Related DisordersSubstance-Related DisordersChemically-Induced DisordersMental Disorders

Intervention Hierarchy (Ancestors)

Behavior TherapyPsychotherapyBehavioral Disciplines and ActivitiesAlcoholsOrganic Chemicals

Central Study Contacts

Stacey Sellers, MS

CONTACT

Julianne Flanagan, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor, Licensed Clinical Psychologist

Study Record Dates

First Submitted

December 21, 2022

First Posted

January 6, 2023

Study Start

March 13, 2023

Primary Completion (Estimated)

March 1, 2028

Study Completion (Estimated)

March 1, 2029

Last Updated

February 5, 2026

Record last verified: 2026-02

Locations