Mapping the Health Status of the Population of French Polynesia: the MATAEA Project

NCT06133400 | Completed

• 3 other identifiers: 2019-ILM-0012019-A01793-542017-069
• Study Type: interventional
• Target: 1,942
• Locations: 1 country
• Sites: 1

Brief Summary

This is a cross-sectional study carried out on a sample of the adult population aged 18 to 69, distributed over the five archipelagos of French Polynesia. Participation in the study involves: agreement to answer a questionnaire to collect information on socio-demographic characteristics, lifestyle habits and medical history; physical measurements (height, weight, waist circumference, blood pressure and skin pigmentation); and agreement to take biological samples (blood, saliva and stool) for biological, genetic and microbiological analyses. The aim of the study is to assess the current health status of the population of French Polynesia and to evaluate the influence of contextual risk factors (lifestyle, place of residence, history of infection) and intrinsic susceptibility factors (genetics, age, gender, microbiota) in relation to non-communicable and infectious diseases.

Conditions

Non Communicable Diseases; Microbiome; Communicable Diseases; Pesticide Exposure; Metal Poison; Genetics Population; Ciguatera

Keywords

cross-sectional survey; non-communicable disease; communicable disease; French Polynesia; population genetics

Outcome Measures

Primary Outcomes (16)

• Prevalence of obesity

  Proportion of participants with indicators of obesity based on physical measurements (BMI, waist circumference) and quantification of lipid levels from blood samples.

  2 years

• Prevalence of diabetes

  Proportion of participants with indicators of diabetes based on self-reported data on diabetes history (previous diagnosis, antidiabetic treatment) and quantification of glycated haemoglobin from blood samples.

  2 years

• Prevalence of cardiovascular diseases

  Proportion of participants with indicators of cardiovascular diseases based on self-reported data on history of hypertension (previous diagnosis, treatment for hypertension), blood pressure measurement, and quantification of lipid levels from blood samples.

  2 years

• Association between non-communicable diseases and behavioral factors

  Calculation of odd ratios to investigate association between non-communicable diseases (obesity, diabetes, cardiovascular diseases) and behavioral factors such as tobacco smoking, alcohol consumption, diet or physical activity data self-reported by the participants in the questionnaire.

  2 years

• Association between non-communicable diseases and physical measurements

  Calculation of odd ratios to investigate association between non-communicable diseases (obesity, diabetes, cardiovascular diseases) and physical measurements such as BMI (based on the BMI formula i.e., weight in kilograms divided by height in meters squared).

  2 years

• Association between non-communicable diseases and blood analyses

  Calculation of odd ratios to investigate association between non-communicable diseases (obesity, diabetes, cardiovascular diseases) and blood analyses (such as glycated haemoglobin and lipid levels).

  2 years

• Seroprevalence of communicable diseases

  Proportion of participants with IgG antibodies, detected in blood samples, specific for different pathogens : arboviruses (four dengue serotypes, Zika, chikungunya), hepatitis B and C viruses, hantaviruses, SARS-CoV-2 and other pathogens known to regularly cause infections in French Polynesia (including influenza viruses, human immunodeficiency virus…). Proportion of participants with positive filarial antigenemia to assess the prevalence of Bancroftian lymphatic filariasis.

  2 years

• Composition of microbiome

  Bacterial DNA sequencing from stool and saliva samples to assess the gut and oral microbiota profiles and association with lifestyle behavior, diet and susceptibility to communicable and non-communicable diseases.

  2 years

• Level of exposure to heavy metals

  Quantification of levels of heavy metals (including mercury and lead) from blood samples and association with lifestyle behavior and diet.

  2 years

• Level of exposure to pesticides

  Quantification of levels of pesticides (including chlordane and toxaphene) from blood samples and association with lifestyle behavior and diet.

  2 years

• Level of exposure to mosquito bites

  Proportion of participants with IgG antibodies targeting mosquito salivary proteins in blood samples to assess the risk of infection by mosquito-borne viruses

  2 years

• Prevalence of ciguatera poisoning

  Estimation of the rate of ciguatera poisoning in the population based on data self-reported by the participants in the questionnaire e.g. the occurrence of symptoms suggestive for ciguatera poisoning at least once in their lifetime

  2 years

• Demographic and adaptive history of French Polynesians using genomics

  Human Whole Genome Sequencing from saliva samples to reconstruct the genetic history of the population of French Polynesia, in terms of both demographic and adaptive history.

  2 years

• Genetic susceptibility to obesity

  Genome-wide association studies to identify human genetic factors that are associated with BMI or lipids levels.

  2 years

• Genetic susceptibility to diabetes

  Genome-wide association studies to identify human genetic factors that are associated with HbA1c.

  2 years

• Genetic susceptibility to communicable diseases

  Genome-wide association studies to identify human genetic factors that are associated with the detection of IgG antibodies specific for different pathogens: arboviruses, hepatitis B and C viruses, hantaviruses, SARS-CoV-2 and other pathogens known to regularly cause infections in French Polynesia (including influenza viruses, human immunodeficiency virus…).

  2 years

Study Arms (1)

Subjects representative of the adult population (18-69 y) of French Polynesia

EXPERIMENTAL

Population sample composed of people aged 18 to 69. These people must have been living in French Polynesia for more than two years at the time of the 2017 census

Other: Questionnaire; Other: Physical measurements; Other: Biological samples

Interventions

Questionnaire OTHER

Questionnaire about socio-demographical status, health status and lifestyle habits

Subjects representative of the adult population (18-69 y) of French Polynesia

Physical measurements OTHER

Measurement of height, weight, waist circumference, blood pressure and skin pigmentation

Subjects representative of the adult population (18-69 y) of French Polynesia

Biological samples OTHER

Collect venous blood, saliva and stool samples

Subjects representative of the adult population (18-69 y) of French Polynesia

Eligibility Criteria

• Age: 18 Years - 69 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• be aged 18 or over and under 70 on the date of recruitment
• having signed the consent form

You may not qualify if:

• Minors
• Pregnant or parturient women, and nursing mothers
• Persons deprived of their liberty by a judicial or administrative decision
• Adults who are the subject of a legal protection measure or who are unable to express their consent
• People undergoing psychiatric care
• Individuals who are not affiliated to a social security scheme or beneficiaries of such a scheme
• Homeless people
• Disabled people (unable to move)
• People unable to answer the questionnaire

Sponsors & Collaborators

• Institut Louis Malardé: lead
• Institut Pasteur: collaborator
• Institut de la Statistique de la Polynésie française: collaborator
• Centre Hospitalier de la Polynésie française: collaborator
• Université de la Polynésie française: collaborator
• Institut National en Santé Publique du Québec: collaborator

Study Sites (1)

Institut Louis Malardé

Papeete, Îles du Vent, 98713, French Polynesia

Location

Related Publications (1)

• Teiti I, Aubry M, Fernandes-Pellerin S, Patin E, Madec Y, Boucheron P, Vanhomwegen J, Torterat J, Lastere S, Olivier S, Jaquaniello A, Roux M, Mendiboure V, Harmant C, Bisiaux A, Rijo de Leon G, Liu D, Bossin H, Mathieu-Daude F, Gatti C, Suhas E, Chung K, Condat B, Ayotte P, Conte E, Jolly N, Manuguerra JC, Sakuntabhai A, Fontanet A, Quintana-Murci L, Cao-Lormeau VM. Unravelling the determinants of human health in French Polynesia: the MATAEA project. Front Epidemiol. 2023 Nov 27;3:1201038. doi: 10.3389/fepid.2023.1201038. eCollection 2023.

  PMID: 38455935 DERIVED

MeSH Terms

Conditions

Noncommunicable Diseases; Communicable Diseases; Heavy Metal Poisoning; Ciguatera Poisoning

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Infections; Poisoning; Chemically-Induced Disorders; Foodborne Diseases

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Van-Mai CAO-LORMEAU, PhD

  Institut Louis Malardé

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 30, 2023
• First Posted: November 15, 2023
• Study Start: November 4, 2019
• Primary Completion: December 8, 2021
• Study Completion: December 8, 2021
• Last Updated: November 18, 2023

Record last verified: 2023-11

Locations

FR (1)