Humanin's Value for Early Diagnosis and Short-term Prognosis in Patients With AKI After Heart Transplantation

NCT06125249 | Unknown

• 1 other identifier: KJ012019455
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to explore the value of Humanin for early diagnosis and short-term prognosis of AKI patients after heart transplantation. The main question it aims to answer are:whether Humanin can be a novel marker for predicting AKI after heart transplantation Researchers will compare the Humanin concentration in patients with AKI did not occur after heart transplantation to see if Humanin can be a novel marker for predicting AKI after heart transplantation

Conditions

Acute Kidney Injury; Heart Transplant Surgery

Outcome Measures

Primary Outcomes (2)

• Humanin concentration

  Highest measured value used

  3 months

• Serum creatinine concentration

  Meets KDIGO's definition of AKI

  3 months

Study Arms (2)

Patients with AKI after heart transplantation

AKI occurs in patients after heart transplantation

Patients did not develop AKI after heart transplantation

Patients who do not develop AKI after heart transplantation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Heart transplant patients from Guangdong Provincial People's Hospital from September 2022 to May 2024

You may qualify if:

• Guangdong Provincial People's Hospital performs heart transplantation；Adult patients ≥ 18 years of age, male or female；Basic renal function is normal before surgery；The patient's baseline medical records are complete, including basic heart diseases, comorbidities, hemoglobin, renal function, urine protein quantification, serum albumin, lactic acid, C-reactive protein, heart transplantation operation time, preoperative and postoperative medication and blood pressure, blood transfusion history, ICU length of stay, cardiac ultrasound (including LVEF), etc；

You may not qualify if:

• Age\< 18 years；Baseline data were missing

Sponsors & Collaborators

• Li zhilian: lead

Study Sites (1)

Guangdong Provincial People's Hospital

Guangdong, Guangzhou, 510000, China

RECRUITING

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• zhilian PP li, doctor

  Guangdong Provincial People's Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

zhilian li, doctor

CONTACT

13580560903; lizhilian@gdph.org.cn

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Deputy Chief Physician

Study Record Dates

• First Submitted: November 5, 2023
• First Posted: November 9, 2023
• Study Start: July 1, 2022
• Primary Completion: June 1, 2024
• Study Completion: June 1, 2024
• Last Updated: November 9, 2023

Record last verified: 2023-11

Locations

CN (1)