NCT06116149

Brief Summary

The primary objective of the STRIVE study is to compare two implementation strategies for Diabetes Prevention Program delivery: an in-person health coach strategy (standard 24 in-person sessions at WIC clinics) vs. a multifaceted technology-assisted health coach implementation strategy (12 in-person sessions at WIC clinics supplemented by technology support) on implementation and health-related outcomes in postpartum women.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
722

participants targeted

Target at P75+ for not_applicable obesity

Timeline
11mo left

Started Dec 2023

Typical duration for not_applicable obesity

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress73%
Dec 2023Apr 2027

First Submitted

Initial submission to the registry

September 29, 2023

Completed
1 month until next milestone

First Posted

Study publicly available on registry

November 3, 2023

Completed
1 month until next milestone

Study Start

First participant enrolled

December 12, 2023

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2026

Expected
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2027

Last Updated

July 25, 2025

Status Verified

July 1, 2025

Enrollment Period

2.8 years

First QC Date

September 29, 2023

Last Update Submit

July 22, 2025

Conditions

Keywords

Diabetes Prevention Program

Outcome Measures

Primary Outcomes (2)

  • Difference in uptake (primary implementation outcome)

    The primary implementation outcome will be the difference between study arms in a composite uptake score, as defined by a composite score consisting of the percent of sessions attended and the percentage of times in which participants record weight, activity, and diet compared to what is recommended by the intervention.

    Measured from baseline to 12 months

  • Difference in mean 12-month weight reduction (primary health-related outcome)

    The primary health-related outcome will be difference in mean weight reduction from baseline to 12 months between study arms

    Measured at 3, 6, 9 and 12 months

Secondary Outcomes (21)

  • Fidelity

    12 months

  • Acceptability

    Measured at baseline, 6, and 12 months

  • Appropriateness

    baseline

  • Feasibility (suitability)

    Baseline

  • Adoption (WIC clinics)

    Baseline

  • +16 more secondary outcomes

Other Outcomes (2)

  • Sustainability (DPP coordinators): comparison of perceived sustainability of the two implementation strategies among WIC staff

    18 months

  • Sustainability (Participants): comparison of the proportion of participants maintaining DPP goals at six months after their participation in the DPP has ended

    18 months

Study Arms (2)

In-person health coach strategy

ACTIVE COMPARATOR

Delivery of 24 health coaching sessions in-person by health coaches over 1 year. Standard delivery of 24-sessions of the Group Lifestyle Balance (GLB) behavioral intervention in WIC clinics. The GLB was adapted from the original Lifestyle Balance behavioral intervention used in the original Diabetes Prevention Program trial for use in community translation and group settings. It focuses on improving diet and physical activity and promoting moderate weight loss through health coaching on behavioral change, including self-monitoring of food intake, physical activity, and weight.

Behavioral: In-person health coach delivery of the GLB

Multifaceted technology-assisted health coach implementation strategy

ACTIVE COMPARATOR

Delivery of 12 health coaching GLB sessions in-person by health coaches over one year; supplemental technology support, including tools for self-monitoring, health coach monitoring, asynchronous delivery of intervention materials, and asynchronous coach and group connection. The GLB was adapted from the original Lifestyle Balance behavioral intervention used in the original Diabetes Prevention Program trial for use in community translation and group settings. It focuses on improving diet and physical activity and promoting moderate weight loss through health coaching on behavioral change, including self-monitoring of food intake, physical activity, and weight.

Behavioral: Technology-assisted health coach delivery of the GLB

Interventions

Delivery of 24 health coaching sessions in-person by health coaches over 1 year. Standard delivery of 24-sessions of the Group Lifestyle Balance (GLB) behavioral intervention in WIC clinics. The GLB was adapted from the original Lifestyle Balance behavioral intervention used in the original Diabetes Prevention Program trial for use in community translation and group settings. It focuses on improving diet and physical activity and promoting moderate weight loss through health coaching on behavioral change, including self-monitoring of food intake, physical activity, and weight.

In-person health coach strategy

Delivery of 12 health coaching GLB sessions in-person by health coaches over one year; supplemental technology support, including tools for self-monitoring, health coach monitoring, asynchronous delivery of intervention materials, and asynchronous coach and group connection. The GLB was adapted from the original Lifestyle Balance behavioral intervention used in the original Diabetes Prevention Program trial for use in community translation and group settings. It focuses on improving diet and physical activity and promoting moderate weight loss through health coaching on behavioral change, including self-monitoring of food intake, physical activity, and weight.

Multifaceted technology-assisted health coach implementation strategy

Eligibility Criteria

Age18 Years+
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Serve a large number of WIC postpartum participants
  • Willing and able to provide space for the study
  • Age 18 or older
  • Gave birth in the past 6 weeks to 12 months
  • Obesity or history of gestational diabetes mellitus (Current BMI ≥30 kg/m², OR Medical-record documented history of gestational diabetes mellitus and BMI ≥25 kg/m²)
  • No self-reported diabetes (other than gestational diabetes)
  • Hemoglobin A1c \<6.5%
  • Not currently pregnant or planning to become pregnant in the next 6 months
  • No plans to move outside of the study region in the next 12 months
  • Access to a smartphone
  • Willing and able to participate in the intervention and provide consent
  • Not an immediate family member of the staff at the WIC clinic
  • Other concerns regarding ability to meet trial requirements, at the discretion of the principal investigator or study coordinator

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Tulane University School of Public Health and Tropical Medicine

New Orleans, Louisiana, 70112, United States

RECRUITING

MeSH Terms

Conditions

ObesityDiabetes, GestationalPrediabetic StateHyperglycemia

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsPregnancy ComplicationsFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesDiabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesEndocrine System Diseases

Central Study Contacts

Tara Dobson, BA

CONTACT

Kirsten Dorans, ScD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Masking Details
Due to the nature of the cluster design and intervention program, the study participants, health coaches, DPP Coordinators, WIC clinic staff, and research staff who collect clinical outcome data will not be blinded.
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: Cluster-randomization of 38 Women, Infants, and Children (WIC) clinics
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 29, 2023

First Posted

November 3, 2023

Study Start

December 12, 2023

Primary Completion (Estimated)

October 1, 2026

Study Completion (Estimated)

April 1, 2027

Last Updated

July 25, 2025

Record last verified: 2025-07

Data Sharing

IPD Sharing
Will share

Our study data sharing plan will comply with all NIH policies for data sharing. Data sharing will be implemented in a timely manner. Study data, including data from baseline and follow-up visits, will be prepared sharing. Data will be prepared by the study data manager/biostatistician. These data will be free of identifiers that allow identification of individual research participants either directly or through "deductive disclosure." We are very open to sharing data enthusiastically with the general scientific community, since we also believe in the added value of other investigators working on these data.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
Data sets will be prepared for sharing no later than 3 years after the end of the final patient follow-up visit or 2 years after the main paper of the trial has been published, whichever comes first.
Access Criteria
We will offer opportunities for outside investigators to collaborate with us using complete study data.

Locations