NCT06112860

Brief Summary

The goal of this study is to better understand if, in patients with mild to moderate hearing loss who are also experiencing mild cognitive impairment (MCI) or Alzheimer's disease and related dementias (ADRD), Over-the-Counter (OTC) hearing aids:

  1. 1.improve communication
  2. 2.Whether the magnitude of benefit depends on the patient's level of cognitive disability,
  3. 3.Whether alternative remediation (such as targeted communication strategies) offer similar benefits.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for not_applicable

Timeline
8mo left

Started Jul 2024

Typical duration for not_applicable

Geographic Reach
1 country

3 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress73%
Jul 2024Dec 2026

First Submitted

Initial submission to the registry

October 25, 2023

Completed
8 days until next milestone

First Posted

Study publicly available on registry

November 2, 2023

Completed
9 months until next milestone

Study Start

First participant enrolled

July 23, 2024

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2026

Last Updated

September 19, 2025

Status Verified

September 1, 2025

Enrollment Period

2.4 years

First QC Date

October 25, 2023

Last Update Submit

September 15, 2025

Conditions

Keywords

Over-the-counter Hearing Aids

Outcome Measures

Primary Outcomes (1)

  • Perception of Conversation Index - Dementia Alzheimer's Type (PCI-DAT)

    A questionnaire completed by the communication partner of the individual with MCI and hearing loss. On this scale, higher scores reflect more frequent and more problematic conversation difficulties; item possible scores range from 0 (not problematic) to 7 (.very problematic)

    Baseline at enrollment, then after 4 weeks of using each intervention

Secondary Outcomes (1)

  • Hearing Handicap Inventory for the Elderly (HHIE)

    Baseline at enrollment, then after 4 weeks of using each intervention

Other Outcomes (3)

  • Conversation Analysis

    4 weeks after first intervention

  • Adherence

    4 weeks after each intervention

  • Usability

    4 weeks after OTC intervention

Study Arms (2)

OTC Hearing Aid First

OTHER

Participants will be provided a pair of OTC hearing aids (experimental) with typical directions and use for 4 weeks before outcome measures will be assessed. After which, participants will then receive the communication strategies information/counseling (control) and have outcome measures assessed after 4 weeks.

Device: Over the counter hearing aidBehavioral: Communication Strategies Information/Counseling

Communication Strategies First

OTHER

Participants will receive the communication strategies information/counseling intervention (control) first. Outcome measures will be assessed at 4 weeks. After which, participants will then be given a pair of OTC hearing aids (experimental) with typical directions and use for four weeks before having outcome measures assessed.

Device: Over the counter hearing aidBehavioral: Communication Strategies Information/Counseling

Interventions

An over the counter hearing aid is a device that provides amplification appropriate for individuals with mild to moderate hearing loss. Participants will receive the devices with typical directions and have one scheduled remote visit one week after receiving devices with an audiologist.

Also known as: OTC hearing aid
Communication Strategies FirstOTC Hearing Aid First

Communication Strategies provide information meant to help an individual compensate for hearing loss. The information provides tips both for the individual with hearing loss and for those communicating. People who choose not to pursue hearing aids will typically be given communication strategies information to help them manage their hearing loss. Participants will receive the counseling information in the mail and then have a 1 week follow-up appointment with an audiologist.

Also known as: Communication Strategies
Communication Strategies FirstOTC Hearing Aid First

Eligibility Criteria

Age60 Years - 90 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Over 60 years of age
  • Mild dementia or mild cognitive impairment. Diagnosis will be made at participating memory evaluation centers (see recruitment).
  • Mild to moderate bilateral hearing loss and no current hearing aid use.
  • A communication partner who is able and willing to participate in the study.
  • No vision impairment that would interfere with the ability to complete study tasks (i.e., legally blind, severe cataracts, or macular degeneration)
  • Able to provide own consent as evaluated by the Consent Assessment

You may not qualify if:

  • Clinically significant unstable or progressive medical conditions, or conditions which, in the opinion of the investigator(s) places the participant at unacceptable risk if he or she were to participate in the study.
  • History of unresolved communication difficulties following another neurological problem (i.e., stroke or brain tumor), neurodevelopmental disorder (i.e., Down's syndrome), or head/neck cancer
  • Positive history of major psychiatric disorder (i.e., schizophrenia, significant untreated depression)
  • Co-enrolled in other intervention studies targeting hearing, language, or communication strategies.
  • History or current fluctuating hearing loss

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Northwestern University HA Lab

Evanston, Illinois, 60201, United States

RECRUITING

La Crosse Mayo Clinic

La Crosse, Wisconsin, 54601, United States

ENROLLING BY INVITATION

UW Madison

Madison, Wisconsin, 53706, United States

RECRUITING

MeSH Terms

Conditions

Hearing LossCognitive DysfunctionAlzheimer Disease

Interventions

Counseling

Condition Hierarchy (Ancestors)

Hearing DisordersEar DiseasesOtorhinolaryngologic DiseasesSensation DisordersNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsCognition DisordersNeurocognitive DisordersMental DisordersDementiaBrain DiseasesCentral Nervous System DiseasesTauopathiesNeurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Mental Health ServicesBehavioral Disciplines and ActivitiesCommunity Health ServicesHealth ServicesHealth Care Facilities Workforce and Services

Study Officials

  • Pamela Souza, PhD

    Northwestern University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
Those listening and scoring recorded tasks will be blinded to which group the participants are in.
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor, Otolaryngology; Communication Sciences and Disorders

Study Record Dates

First Submitted

October 25, 2023

First Posted

November 2, 2023

Study Start

July 23, 2024

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2026

Last Updated

September 19, 2025

Record last verified: 2025-09

Data Sharing

IPD Sharing
Will not share

Locations