NCT06109870

Brief Summary

Cervical cancer is a disease that is preventable through vaccination against the virus that causes it, human papillomavirus (HPV), and through screening and treatment of cervical disease before it becomes cancet.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
920

participants targeted

Target at P75+ for not_applicable

Timeline
52mo left

Started Oct 2023

Longer than P75 for not_applicable

Geographic Reach
1 country

2 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress38%
Oct 2023Aug 2030

First Submitted

Initial submission to the registry

October 25, 2023

Completed
5 days until next milestone

Study Start

First participant enrolled

October 30, 2023

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 31, 2023

Completed
4.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2028

Expected
2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2030

Last Updated

March 4, 2026

Status Verified

March 1, 2026

Enrollment Period

4.8 years

First QC Date

October 25, 2023

Last Update Submit

March 2, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 5.0

    through study completion; an average 1 year.

Study Arms (1)

PRECEDE-PROCEED

EXPERIMENTAL

To identify predisposing, enabling, and reinforcing factors that could influence women's decision to participate in self-sample HPV testing and diagnostic follow-up.

Behavioral: PRECEDE-PROCEED

Interventions

PRECEDE-PROCEEDBEHAVIORAL

delivered self-sampling (CHWSS) to increase screening participation.

PRECEDE-PROCEED

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • To be eligible to participate in this study, an individual must meet all of the following criteria:
  • Provision of signed and dated informed consent form
  • Currently resident in RGV or other low-resource community in Texas
  • Stated willingness to comply with all study procedures
  • Females; Age ≥25 years
  • Have no history of hysterectomy with removal of the cervix
  • Have no history of cervical cancer or high-grade dysplasia
  • Have not had a Pap test in the past 3.5 years or Pap/HPV co-test in the past 5.5 years.

You may not qualify if:

  • An individual who meets any of the following criteria will be excluded from participation in this study:
  • Unable to communicate in English or Spanish
  • Lack valid telephone contact information
  • Report being currently pregnant.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

University of Texas at Austin

Austin, Texas, 78712, United States

RECRUITING

M D Anderson Cancer Center

Houston, Texas, 77030, United States

RECRUITING

Related Publications (1)

  • Fallah PN, Bowman P, Tran C, Chen V, Pippin M, Varon ML, Baker E, Milan J, Parker SL, Lezama-Sierra J, Munsell MF, Desravines N, Lavie I, Batman S, Montealegre J, Schmeler KM, Williams-Brown MY, Salcedo MP. Implementation of Human Papillomavirus Self-Collection and Barriers to Follow-Up Among Unhoused Individuals in Texas: The EMPOWER Study. Obstet Gynecol. 2025 Nov 1;146(5):710-717. doi: 10.1097/AOG.0000000000006003. Epub 2025 Jul 17.

Related Links

Study Officials

  • Jane Montealegre, M D

    M.D. Anderson Cancer Center

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Jane Montealegre, M D

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 25, 2023

First Posted

October 31, 2023

Study Start

October 30, 2023

Primary Completion (Estimated)

August 31, 2028

Study Completion (Estimated)

August 31, 2030

Last Updated

March 4, 2026

Record last verified: 2026-03

Locations