Which Factors Are Relevant for Treatment Outcome in Dialectical Behaviour Therapy for Borderline Personality Disorder?

NCT06106555 | Recruiting

• 1 other identifier: Dnr 2023-03990-01
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this project is to investigate factors that contribute to the success and lack of success in DBT among individuals with BPD and a history of self-harm in a clinical psychiatric setting.

1. 1.Do certain personality factors and identity disturbance predict the treatment outcome of DBT in individuals with BPD?
2. 2.Do changes in identity disturbance, self-hate, or emotion regulation mediate the treatment outcome of DBT in individuals with BPD?
3. 3.Do specific personality profiles moderate the treatment outcomes of DBT for individuals with BPD?
4. 4.When does the primary treatment effect occur, and does this effect persist after a 12-month follow-up period?

Conditions

Borderline Personality Disorder; Non-suicidal Self-injury; Deliberate Self Harm

Keywords

Borderline Personality Disorder; Dialectical Behavior Therapy; Deliberate Self-Harm; Non-suicidal Self-injury; Self-concept; Personality

Outcome Measures

Primary Outcomes (1)

• Five Self-harm Behaviour Groupings Measure (5S-HM)

  Indirect and direct self-harm

  Treatment start, 3,6,9 and at end of treatment and at follow up at 24 months.

Secondary Outcomes (5)

• The World Health Organization Disability Assessment Schedule II (WHODAS 2)

  Treatment start, 3,6,9 and at end of treatment and at follow up at 24 months.

• The Borderline Symptom List-23 (BSL-23)

  Treatment start, 3,6,9 and at end of treatment and at follow up at 24 months.

• The Level of Personality Functioning Scale-Brief Form 2.0 (LPFS 2.0)

  Treatment start, 3,6,9 and at end of treatment and at follow up at 24 months.

• The Personality Inventory for DSM-V Brief Form (PID-5-BF)

  Treatment start, 3,6,9 and at end of treatment and at follow up at 24 months.

• Hospitilization days

  Treatment at end of treatment and at follow up at 24 months.

Study Arms (1)

Individuals with BPD

Individuals with BPD, as defined by the DSM-V, and a recent history (past 12 months) of self-harming behaviour.

Behavioral: Dialectibal Behaviour Therapy

Interventions

Dialectibal Behaviour Therapy BEHAVIORAL

Standard Dialectical Behaviour Therapy of up to 12 months as described Professor Linehan

Individuals with BPD

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults with Borderline personality disorder in a specialized psychiatric setting. A majority of the individuals will have comorbid psychiatric conditions and have been offered other pharmacological and psychological treatments through their GP or a general psychiatric outpatient unit prior to the study intervention. Other treatments are permitted for inclusion in this study.

You may qualify if:

• Borderline personality disorder as defined by the DSM-V (assessed with SCID or uquivalent).
• Self-harm over the past 12 months
• Offered DBT at the Lund adult psychiatric clinic

You may not qualify if:

• Unable to read or communicate in Swedish

Sponsors & Collaborators

• Region Skane: lead
• Department of Psychology. Lund University.: collaborator
• University of Toronto: collaborator
• Lund University: collaborator

Study Sites (1)

Lund adult psychiatric hospital

Lund, Skåne County, 22185, Sweden

RECRUITING

Related Publications (17)

• Alvarez-Tomas I, Ruiz J, Guilera G, Bados A. Long-term clinical and functional course of borderline personality disorder: A meta-analysis of prospective studies. Eur Psychiatry. 2019 Feb;56:75-83. doi: 10.1016/j.eurpsy.2018.10.010. Epub 2018 Dec 24.

  PMID: 30599336 BACKGROUND

• van Asselt AD, Dirksen CD, Arntz A, Severens JL. The cost of borderline personality disorder: societal cost of illness in BPD-patients. Eur Psychiatry. 2007 Sep;22(6):354-61. doi: 10.1016/j.eurpsy.2007.04.001. Epub 2007 Jun 4.

  PMID: 17544636 BACKGROUND

• Chen SY, Cheng Y, Zhao WW, Zhang YH. Effects of dialectical behaviour therapy on reducing self-harming behaviours and negative emotions in patients with borderline personality disorder: A meta-analysis. J Psychiatr Ment Health Nurs. 2021 Dec;28(6):1128-1139. doi: 10.1111/jpm.12797. Epub 2021 Sep 20.

  PMID: 34519138 BACKGROUND

• Cipriano A, Cella S, Cotrufo P. Nonsuicidal Self-injury: A Systematic Review. Front Psychol. 2017 Nov 8;8:1946. doi: 10.3389/fpsyg.2017.01946. eCollection 2017.

  PMID: 29167651 BACKGROUND

• Ellison WD, Rosenstein LK, Morgan TA, Zimmerman M. Community and Clinical Epidemiology of Borderline Personality Disorder. Psychiatr Clin North Am. 2018 Dec;41(4):561-573. doi: 10.1016/j.psc.2018.07.008. Epub 2018 Oct 16.

  PMID: 30447724 BACKGROUND

• Gad MA, Pucker HE, Hein KE, Temes CM, Frankenburg FR, Fitzmaurice GM, Zanarini MC. Facets of identity disturbance reported by patients with borderline personality disorder and personality-disordered comparison subjects over 20 years of prospective follow-up. Psychiatry Res. 2019 Jan;271:76-82. doi: 10.1016/j.psychres.2018.11.020. Epub 2018 Nov 10.

  PMID: 30469092 BACKGROUND

• Gratz KL, Bardeen JR, Levy R, Dixon-Gordon KL, Tull MT. Mechanisms of change in an emotion regulation group therapy for deliberate self-harm among women with borderline personality disorder. Behav Res Ther. 2015 Feb;65:29-35. doi: 10.1016/j.brat.2014.12.005. Epub 2014 Dec 13.

  PMID: 25557395 BACKGROUND

• Weekers LC, Hutsebaut J, Kamphuis JH. The Level of Personality Functioning Scale-Brief Form 2.0: Update of a brief instrument for assessing level of personality functioning. Personal Ment Health. 2019 Feb;13(1):3-14. doi: 10.1002/pmh.1434. Epub 2018 Sep 19.

  PMID: 30230242 BACKGROUND

• Kaufman EA, Meddaoui B. Identity pathology and borderline personality disorder: an empirical overview. Curr Opin Psychol. 2021 Feb;37:82-88. doi: 10.1016/j.copsyc.2020.08.015. Epub 2020 Aug 25.

  PMID: 32932110 BACKGROUND

• Krueger RF, Derringer J, Markon KE, Watson D, Skodol AE. Initial construction of a maladaptive personality trait model and inventory for DSM-5. Psychol Med. 2012 Sep;42(9):1879-90. doi: 10.1017/S0033291711002674. Epub 2011 Dec 8.

  PMID: 22153017 BACKGROUND

• Kroger C, Harbeck S, Armbrust M, Kliem S. Effectiveness, response, and dropout of dialectical behavior therapy for borderline personality disorder in an inpatient setting. Behav Res Ther. 2013 Aug;51(8):411-6. doi: 10.1016/j.brat.2013.04.008. Epub 2013 May 14.

  PMID: 23727659 BACKGROUND

• Mehlum L. Mechanisms of change in dialectical behaviour therapy for people with borderline personality disorder. Curr Opin Psychol. 2021 Feb;37:89-93. doi: 10.1016/j.copsyc.2020.08.017. Epub 2020 Aug 25.

  PMID: 32979766 BACKGROUND

• McMain SF, Fitzpatrick S, Boritz T, Barnhart R, Links P, Streiner DL. Outcome Trajectories and Prognostic Factors for Suicide and Self-Harm Behaviors in Patients With Borderline Personality Disorder Following One Year of Outpatient Psychotherapy. J Pers Disord. 2018 Aug;32(4):497-512. doi: 10.1521/pedi_2017_31_309. Epub 2017 Sep 14.

  PMID: 28910214 BACKGROUND

• Meuldijk D, McCarthy A, Bourke ME, Grenyer BF. The value of psychological treatment for borderline personality disorder: Systematic review and cost offset analysis of economic evaluations. PLoS One. 2017 Mar 1;12(3):e0171592. doi: 10.1371/journal.pone.0171592. eCollection 2017.

  PMID: 28249032 BACKGROUND

• Schmitgen MM, Niedtfeld I, Schmitt R, Mancke F, Winter D, Schmahl C, Herpertz SC. Individualized treatment response prediction of dialectical behavior therapy for borderline personality disorder using multimodal magnetic resonance imaging. Brain Behav. 2019 Sep;9(9):e01384. doi: 10.1002/brb3.1384. Epub 2019 Aug 14.

  PMID: 31414575 BACKGROUND

• Levi FA, Hrushesky WJ, Blomquist CH, Lakatua DJ, Haus E, Halberg F, Kennedy BJ. Reduction of cis-diamminedichloroplatinum nephrotoxicity in rats by optimal circadian drug timing. Cancer Res. 1982 Mar;42(3):950-5.

  PMID: 7199382 BACKGROUND

• Woodbridge J, Reis S, Townsend ML, Hobby L, Grenyer BFS. Searching in the dark: Shining a light on some predictors of non-response to psychotherapy for borderline personality disorder. PLoS One. 2021 Jul 27;16(7):e0255055. doi: 10.1371/journal.pone.0255055. eCollection 2021.

  PMID: 34314461 BACKGROUND

MeSH Terms

Conditions

Borderline Personality Disorder; Self-Injurious Behavior

Condition Hierarchy (Ancestors)

Personality Disorders; Mental Disorders; Behavioral Symptoms; Behavior

Central Study Contacts

Magnus Nilsson, PhD

CONTACT

046174925; magnus.per.nilsson@skane.se

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 24, 2023
• First Posted: October 30, 2023
• Study Start: September 1, 2023
• Primary Completion (Estimated): August 31, 2027
• Study Completion (Estimated): August 31, 2027
• Last Updated: June 25, 2025

Record last verified: 2025-06

Locations

SE (1)