Relevance and Efficiency of SecOnd Line Workup for Uveitis

NCT06102408 | Unknown

• 1 other identifier: 2023PI190
• Study Type: observational
• Target: 300
• Locations: 0 countries
• Sites: N/A

Brief Summary

The first-line etiological workup is currently poorly codified, and some patients undergo sequential investigations. However, the reason which lead the clinician to perform subsequent exams, and the relevance of such exams, remain to be determined. The main objective of the study was to assess the relevance of a second-line workup of patients with uveitis.

Conditions

Uveitis

Outcome Measures

Primary Outcomes (1)

• patients undergoing a second line etiological workup

  percentage of patients undergoing a second line etiological workup

  through study completion, an average of 18 months

Study Arms (3)

Patients with only one etiological workup

patients who underwent only one set of exams for etiological investigations of uveitis

Other: second line investigations for uveitis etiological workup

Patients without diagnostic modification subsequently to the second etiological workup

Patients who underwent a second etiological workup, independently of the results of the fist line investigations, and whose diagnosis was not modified by the second line investigations.

Other: second line investigations for uveitis etiological workup

Patients with diagnostic modification subsequently to the second etiological workup

Patients who underwent a second etiological workup, independently of the results of the fist line investigations, and whose diagnosis was modified by the second line investigations.

Other: second line investigations for uveitis etiological workup

Interventions

second line investigations for uveitis etiological workup OTHER

Biological, radiological or histological investigations performed after a first line etiological workup. Investigations conducted following abnormal resultats of first line exams were not considered as second line exams (e.g. : bronchoscopy performed after abrnomal CT scan).

Patients with diagnostic modification subsequently to the second etiological workup; Patients with only one etiological workup; Patients without diagnostic modification subsequently to the second etiological workup

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

adult pateints with uveitis requiring at least one etiological workup.

You may qualify if:

• adult patient
• at least one etiological workup in our center

You may not qualify if:

• only episode of acute anterior uveitis quickly responding to topical treatments
• diagnostic ophthalmologically obvious
• opposition to collection of data

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Related Publications (6)

• Hwang DK, Chou YJ, Pu CY, Chou P. Epidemiology of uveitis among the Chinese population in Taiwan: a population-based study. Ophthalmology. 2012 Nov;119(11):2371-6. doi: 10.1016/j.ophtha.2012.05.026. Epub 2012 Jul 17.

  PMID: 22809756 BACKGROUND

• Dandona L, Dandona R, John RK, McCarty CA, Rao GN. Population based assessment of uveitis in an urban population in southern India. Br J Ophthalmol. 2000 Jul;84(7):706-9. doi: 10.1136/bjo.84.7.706.

  PMID: 10873978 BACKGROUND

• Jabs DA, Nussenblatt RB, Rosenbaum JT; Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol. 2005 Sep;140(3):509-16. doi: 10.1016/j.ajo.2005.03.057.

  PMID: 16196117 BACKGROUND

• Smith JR, Rosenbaum JT. Management of uveitis: a rheumatologic perspective. Arthritis Rheum. 2002 Feb;46(2):309-18. doi: 10.1002/art.503. No abstract available.

  PMID: 11840433 BACKGROUND

• Selmi C. Diagnosis and classification of autoimmune uveitis. Autoimmun Rev. 2014 Apr-May;13(4-5):591-4. doi: 10.1016/j.autrev.2014.01.006. Epub 2014 Jan 12.

  PMID: 24424168 BACKGROUND

• de Parisot A, Jamilloux Y, Kodjikian L, Errera MH, Sedira N, Heron E, Perard L, Cornut PL, Schneider C, Riviere S, Olle P, Pugnet G, Cathebras P, Manoli P, Bodaghi B, Saadoun D, Baillif S, Tieulie N, Andre M, Chiambaretta F, Bonin N, Bielefeld P, Bron A, Mouriaux F, Bienvenu B, Amamra N, Guerre P, Decullier E, Seve P; ULISSE group. Evaluating the cost-consequence of a standardized strategy for the etiological diagnosis of uveitis (ULISSE study). PLoS One. 2020 Feb 14;15(2):e0228918. doi: 10.1371/journal.pone.0228918. eCollection 2020.

  PMID: 32059021 BACKGROUND

MeSH Terms

Conditions

Uveitis

Condition Hierarchy (Ancestors)

Uveal Diseases; Eye Diseases

Central Study Contacts

Thomas Moulinet, MD

CONTACT

+3383155304; t.moulinet@chru-nancy.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 22, 2023
• First Posted: October 26, 2023
• Study Start: November 15, 2023
• Primary Completion: December 15, 2023
• Study Completion: December 25, 2023
• Last Updated: October 27, 2023

Record last verified: 2023-10