A Study of Uveitis in Children <18 Years of Age

NCT07518134 | Recruiting DMC

• 1 other identifier: UV1
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 4

Brief Summary

The goal of this observational study is to collect data regarding clinical features and current/past treatments in children under 18 with uveitis. The main questions it aims to answer are:

• What are the frequency of uveitis subtypes in children?
• What are clinical and demographic characteristics overall and within each type of uveitis? Participants will complete one enrollment visit with their doctor. Participants with uveitis onset \<6 months from enrollment date will also partake in a 12 month chart review.

Conditions

Uveitis

Keywords

pediatric; uveitis

Outcome Measures

Primary Outcomes (1)

• Frequency of uveitis subtypes in children <18 years of age

  Enrollment

Study Arms (2)

Children diagnosed with uveitis - established cases

Children diagnosed with uveitis (onset \> 6 months), either active or inactive with or without current treatment at time of enrollment.

Children diagnosed with uveitis - incident cases

Children diagnosed with uveitis (onset ≤ 6 months), either active or inactive with or without current treatment at time of enrollment.

Eligibility Criteria

• Age: Up to 17 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

Children \<18 years with active or inactive uveitis.

You may qualify if:

• Age:
• Incident cases (onset ≤ 6 months) \<17 years
• Established cases (onset \> 6 months) \<18 years
• Diagnosis of any type of uveitis (infectious or noninfectious) in any location except traumatic and post-operative uveitis.
• Active or inactive uveitis with any treatment status (current / prior / none \[but under surveillance\]).

You may not qualify if:

• Bilateral uveitis with differing etiologies
• Traumatic uveitis
• Post-operative uveitis
• Immediate family member (spouse, biological or legal guardian, child, sibling, parent) who is an investigative site personnel directly affiliated with this study or who is an employee of JAEB Center for Health Research.
• Ocular disease related to Retinoblastoma, Coat's disease, retinitis pigmentosa, inherited retinal degeneration, Juvenile xanthogranuloma (JXG), or leukemia/malignancy within the eye.

Sponsors & Collaborators

• Jaeb Center for Health Research: lead

Study Sites (4)

Department of Ophthalmology, Boston University School of Medicine

Boston, Massachusetts, 02118, United States

RECRUITING

Akron Children's Hospital

Akron, Ohio, 44308, United States

RECRUITING

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States

RECRUITING

Pediatric Ophthalmology Associates, Inc.

Columbus, Ohio, 43205, United States

RECRUITING

MeSH Terms

Conditions

Uveitis

Condition Hierarchy (Ancestors)

Uveal Diseases; Eye Diseases

Study Officials

• Kara C LaMattina, MD

  Department of Ophthalmology, Boston University School of Medicine

  STUDY CHAIR

• Virginia Miraldi Utz, MD

  Children's Hospital Medical Center, Cincinnati

  STUDY CHAIR

Central Study Contacts

Julianne Zawadzki, MSPH

CONTACT

813-975-8690; jrobinson@jaeb.org

Raymond Kraker, MSPH

CONTACT

8139758690; rkraker@jaeb.org

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 12 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 1, 2026
• First Posted: April 8, 2026
• Study Start: April 14, 2026
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): April 1, 2028
• Last Updated: May 8, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF

Locations

US (4)