Nailfold Capillaroscopic Assessment in Pediatric Uveitis Patients

NCT06070935 | Completed DMC

• 1 other identifier: Nailfold capillaroscopy
• Study Type: observational
• Target: 46
• Locations: 1 country
• Sites: 1

Brief Summary

Pediatric uveitis accounts for 5-10% of uveitis cases. it may be infectious or noninfectious in etiology. The etiology of noninfectious uveitis may be autoimmune. The most common causes of pediatric uveitis are idiopathic and juvenile idiopathic arthritis-associated uveitis. Uveitis morbidities in pediatric patients include cataract, glaucoma, and amblyopia. Pediatric uveitis may be accopanied by involvement of the ocular vasculature, such as retinal vasculitis. We hypothesize that there are differences in systemic microcirculation between pediatric uveitis patients and healthy pediatric controls.

Conditions

Uveitis

Outcome Measures

Primary Outcomes (3)

• capillary density by nailfold capillaroscopy

  (number of capillaries per mm)

  6 months

• detection of number of dilated capillaries by nailfold capillaroscopy

  number of dilated capillaries (apex of \>20µm)

  6 months

• detection of other abnormalities as avascular areas, microhemorrhages, and abnormal capillary morphology

  detection of multiple crossings, tortuous, bushy, ramified, non-convex, or bizarre capillaries

  6 months

Secondary Outcomes (1)

• correlation of nailfold findings with uveitis activity

  6 months

Study Arms (2)

pediatric uveitis

pediatric uveitis patients \< 18 years old

healthy subjects

healthy subjects\< 18 years old

Eligibility Criteria

• Age: Up to 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

pediatric uveitis patients and healthy pediatric control

You may qualify if:

• patients with uveitis \< 18 years old

You may not qualify if:

• infectious uveitis
• age \> 18 years old

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Maha Abdelrahman

Asyut, 71515, Egypt

Location

MeSH Terms

Conditions

Uveitis

Condition Hierarchy (Ancestors)

Uveal Diseases; Eye Diseases

Study Officials

• Maha Abdelrahman, MD, PHD

  Assiut University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal invesigator

Study Record Dates

• First Submitted: October 1, 2023
• First Posted: October 6, 2023
• Study Start: January 1, 2024
• Primary Completion: May 30, 2024
• Study Completion: June 30, 2024
• Last Updated: August 15, 2024

Record last verified: 2024-08

Locations

EG (1)