Different Hold Durations in Isometric Exercises

NCT07198204 | Not Yet Recruiting

• 1 other identifier: FPTBSUREC/1207/14925
• Study Type: interventional
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

this stuy tries to evaulate the best contraction (hold time) during isometric effort that can provide the best therapeutic effects on muscular performance in patients with knee osteoarthritis

Conditions

Knee Arthritis Osteoarthritis

Keywords

knee; arthritis; strength; contraction time; isometric

Outcome Measures

Primary Outcomes (4)

• pain by numeric pain rating scale

  The Numeric Pain Rating Scale (NPRS) is the simplest and most commonly used numeric scale to rate pain, ranging from 0 (no pain) to 10 (worst pain). The NPRS will be used for subjective pain measurement, which has good test-retest reliability

  at baseline and after 1month of trreatment

• Function using Western Ontario and McMaster Universities Osteoarthritis

  We will focus only on stiffness and physical function. The Western Ontario and McMaster Universities Osteoarthritis (WOMAC) has been widely used by clinicians in assessing patients with knee OA since it was developed in 1986 (Bellamy, 1995) to evaluate the symptoms of pain, stiffness, and physical function in patients with hip and/or knee OA. It consists of 24 questions and is divided into 3 subgroups: the pain subgroup consists of 5 questions, the stiffness subgroup consists of 2 questions, and the physical function subgroup consists of 17 questions. Each question receives a value between 0 and 4, and the total score is calculated as follows: no difficulty is scored as 0, mild as 1, moderate as 2, severe as 3, and extreme as 4. Higher scores indicate greater physical dysfunction and disability, and thereby worse health-related quality of life

  will be assessed at baseline and after 1 month of treatement

• function using Five Times Sit to Stand Test

  The muscle strength of the lower limbs was measured by the Five-Times-Sit-to-Stand Test (FTSST), in which participants rise from a chair and return to a seated position as quickly as possible with their arms folded across their chests. The time to complete five repetitions was recorded for two separate trials, with a 1-minute rest between each trial. The mean of the two trials was computed and used in the analysis

  at baseline and after 1month of treatment

• muscle strength using the one-repetition maximum (1RM) test for knee extension

  1RM test has good-to-excellent test-retest reliability. the participants will be asked to perform active knee extension against different pregressive increasing weigths to determine the 1 RM. 2 minutes rest will be allowed before each contraction effort to allow recovery of the tested muscle.

  at baseline and after 1 month of treatement

Study Arms (4)

group 1

EXPERIMENTAL

The subjects in this group will perform isometric exercises, including isometric quadriceps, straight-leg raising, and isometric hip adduction exercises for 5 seconds. All exercises will be performed in sets of 12 repetitions: one set twice a day for the 1st week, which will be progressed weekly until three sets twice a day by 3th week. Allow 5 seconds of rest between each repetition and 3 minutes of rest between sets, with a total contraction time of 60 to 180 seconds per session at 30 to 50% of maximum voluntary contraction (MVC).

Other: isometric exercises; Other: therapeutic ultrasound; Other: Transcutanous electrical nerve stimulation

group 2

EXPERIMENTAL

The subjects in this group will perform isometric exercises, including isometric quadriceps, straight leg raising, and isometric hip adduction exercise for 10 sec. All exercises will be performed in sets of 6 repetitions: one set twice a day for the 1st week, which will be progressed weekly until three sets twice a day by 3th week. Allow 10 seconds of rest between each repetition and 3 minutes of rest between sets, with a total contraction time of 60 to 180 seconds per session at 30 to 50% of MVC.

Other: isometric exercises; Other: therapeutic ultrasound; Other: Transcutanous electrical nerve stimulation

group 3

EXPERIMENTAL

The subjects in this group will perform isometric exercises, including isometric quadriceps, straight leg raising, and isometric hip adduction exercise for 20 sec. All exercises will be performed in sets of 3 repetitions: one set twice a day for the 1st week, which will be progressed weekly until three sets twice a day by 3th week. Allow 20 seconds of rest between each repetition and 3 minutes of rest between sets, with a total contraction time of 60 to 180 seconds per session at 30 to 50% of MVC.

Other: isometric exercises; Other: therapeutic ultrasound; Other: Transcutanous electrical nerve stimulation

control group

ACTIVE COMPARATOR

The control group will receive ultrasound therapy and TENS only.

Other: therapeutic ultrasound; Other: Transcutanous electrical nerve stimulation

Interventions

isometric exercises OTHER

Isometric quadriceps exercise: Patients lie in a supine position. A rolled-up towel was put beneath the knee. They were instructed to maximally activate their thigh muscles to straighten their knee and hold the contraction for 5 seconds (Group A), 10 seconds (Group B), or 20 seconds (Group C).

group 1; group 2; group 3

therapeutic ultrasound OTHER

all patients will reciece ultrasound for 5 minutes using 1MHz frequency, 0.8 wc2, 5cm2 head with adequate gel as a coupling medium

control group; group 1; group 2; group 3

Transcutanous electrical nerve stimulation OTHER

all participants will recieve TENS for 30 minutes per session. the parameters will be Burst TENS, with main frequency of 100Hz, burst frequency of 4 Hz, intensity to the comfortable muscle twitch, electrodes size according to the size of the patients knee.

control group; group 1; group 2; group 3

Eligibility Criteria

• Age: 40 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• prediagnosed case of knee OA as per the American College of Rheumatology (ACR) and radiological evidence of primary osteoarthritis of grade 3 or less on the Kellgren Lawrence scale;
• age between 40-65 years, including both men and women.
• unilateral or bilateral involvement (in the case of bilateral involvement, the more symptomatic knee was included).

You may not qualify if:

• Other knee joint pathologies, eg, Chondromalacia patella, plica syndrome,
• Neurological disorders.
• Patients having lower extremity injury/surgeries in the past 6 months,
• Hip or knee fractures or deformity,
• joint infections and inflammatory joint disease,
• physical therapy on the knee within the last 3 months or steroid injections,

Sponsors & Collaborators

• University of Hail: lead

MeSH Terms

Conditions

Arthritis

Interventions

Exercise; Ultrasonic Therapy

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Diathermy; Hyperthermia, Induced; Therapeutics

Central Study Contacts

Hisham Hussein, PhD

CONTACT

+966543704108; drhisham3000@cu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: September 15, 2025
• First Posted: September 30, 2025
• Study Start: November 30, 2025
• Primary Completion: April 30, 2026
• Study Completion: April 30, 2026
• Last Updated: September 30, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share