Blood Indices of Systemic Inflammation in Critically Ill Patients With Abdominal Sepsis

NCT06095830 | Unknown

• 1 other identifier: Abdominal sepsis in ICU
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to clarify the role of blood indices of systemic inflammation in ICU-admitted patients with abdominal sepsis to assess their diagnostic significance as well as their prognostic value.

Conditions

Abdominal Sepsis; Critically Ill

Keywords

Blood indices of systemic inflammation

Outcome Measures

Primary Outcomes (1)

• Estimation of the prognostic value of blood indices of systemic inflammation

  Correlate between the blood indices of systemic inflammation and the prognosis of the patients.

  Baseline

Study Arms (3)

Group 1

Patients that recovered from sepsis without complications

Diagnostic Test: Complete blood count

Group 2

Patients that didn't recover from sepsis. Further subdivided into: Group 2-A: developed complications Group 2-B: non-surviving

Diagnostic Test: Complete blood count

Group 3

Control group of healthy individuals

Diagnostic Test: Complete blood count

Interventions

Complete blood count DIAGNOSTIC_TEST

Complete blood count done on admission and on discharge for patients, from which the blood indices of systemic inflammation will be calculated and correlated with outcome

Group 1; Group 2; Group 3

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A total sample size of 120 individuals

You may qualify if:

• Patients above the age of 18 years old.
• Patients fulfilling the Systemic Inflammatory Response Syndrome (SIRS) criteria.
• Patients with an established diagnosis of abdominal sepsis, clinically and by investigations.

You may not qualify if:

• Patients below the age of 18 years.
• Patients with haematological disorders.
• Patients with concomitant severe morbidity affecting the prognosis other than sepsis e.g. hypovolemic shock, brainstem infarction, pulmonary embolism, etc.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut University Hospitals

Asyut, 71515, Egypt

Location

MeSH Terms

Conditions

Intraabdominal Infections; Critical Illness

Interventions

Blood Cell Count

Condition Hierarchy (Ancestors)

Infections; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Cell Count; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Hematologic Tests; Investigative Techniques; Cell Physiological Phenomena; Blood Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Study Officials

• Safaa Abdelsattar, Prof

  Assiut University

  STUDY DIRECTOR

• Dina Hammad, Prof

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Mohammed K. Abdellah, Bachelor

CONTACT

+201220930015; dr.mohammed.khaled7@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: October 18, 2023
• First Posted: October 23, 2023
• Study Start: November 1, 2023
• Primary Completion: November 1, 2025
• Study Completion: December 1, 2025
• Last Updated: October 23, 2023

Record last verified: 2023-10

Locations

EG (1)