Disease Activity in RA and SLE Patients and Its Relation to Muscle Performance,Fatigue and Blood Parameters

NCT03728231 | Unknown

• 1 other identifier: DAS in RA and SLE
• Study Type: observational
• Target: 150
• Locations: 0 countries
• Sites: N/A

Brief Summary

Assessment of disease activity in Rheumatoid Arthritis and Systemic lupus patients related to muscle performance, fatigue and blood parameters

Conditions

Rheumatic Diseases

Outcome Measures

Primary Outcomes (1)

• estimation of muscle performance in Rheumatoid arthritis and Systemic lupus patients by 30_s chair stand test (repetition 4_12) .

  use of 30\_s chair stand test(repetition 4\_12) in detection of degree of muscle performance in Rheumatoid arthritis and Systemic lupus patients .

  6 months

Study Arms (3)

Fifty patients with RA.

-CBC with assessment of NLR and PLR. Immumological tests (RF, ANA, anti-ds DNA). * Functional Performance Tests:(12) * Fatigue severity scale (13). * Short-Form Health Survey 36 (SF-36) (14). * the short version of the International Physical activity Questionnaire (s-IPAQ) (15). * frequency intensity time (FIT) index of kasari (16). :\* Disease activity Score(DAS)(17)

Other: Complete blood count

Fifty patients with SLE.

CBC with assessment of NLR and PLR. Immumological tests (RF, ANA, anti-ds DNA). * Functional Performance Tests:(12) * Fatigue severity scale (13). * Short-Form Health Survey 36 (SF-36) (14). * the short version of the International Physical activity Questionnaire (s-IPAQ) (15). * frequency intensity time (FIT) index of kasari (16). :\* SLE Disease activity Index(SLEDAI)(18)

Other: Complete blood count

Fifty apparently healthy controls

CBC with assessment of NLR and PLR. Immumological tests (RF, ANA, anti-ds DNA). * Functional Performance Tests:(12) * Fatigue severity scale (13). * Short-Form Health Survey 36 (SF-36) (14). * the short version of the International Physical activity Questionnaire (s-IPAQ) (15). * frequency intensity time (FIT) index of kasari (16).

Other: Complete blood count

Interventions

Complete blood count OTHER

taking blood sample from venous blood

Also known as: Immunological tests, ESR and CRP

Fifty apparently healthy controls; Fifty patients with RA.; Fifty patients with SLE.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Fifty patients diagnosed Rheumatoid arthritis according to 1987ACR or 2010ACR\\EULAR criteria Fifty patients diagnosed Systemic lupus according to 1982 ACRor 2012ACR criteria Fifty Apperantly healthy persons

You may qualify if:

• RA diagnosis according to 1987ACR criteria,or 2010 ACR/EULAR criteria
• SLE diagnosis according to 1982 ACRor 2012 ACRcriteria
• Patients aged \> 18 years.
• Stable disease with no activity during last 3 months.
• Regular medication in last 3 months.

You may not qualify if:

• Subjects with hematologic disorders other than anaemia.
• Concomitant infectious or inflammatory diseases such as ulcerative colitis.
• Liver or kidney disease.
• Coronary heart disease.
• Other immunological diseases.
• Pregnant ladies.
• Patients with end stage organ failure.
• Patients with malignancies.
• Patients receiving any medications affect blood picture.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Biolo G, Cederholm T, Muscaritoli M. Muscle contractile and metabolic dysfunction is a common feature of sarcopenia of aging and chronic diseases: from sarcopenic obesity to cachexia. Clin Nutr. 2014 Oct;33(5):737-48. doi: 10.1016/j.clnu.2014.03.007. Epub 2014 Mar 29.

  PMID: 24785098 BACKGROUND

• Hakkinen A, Kautiainen H, Hannonen P, Ylinen J, Makinen H, Sokka T. Muscle strength, pain, and disease activity explain individual subdimensions of the Health Assessment Questionnaire disability index, especially in women with rheumatoid arthritis. Ann Rheum Dis. 2006 Jan;65(1):30-4. doi: 10.1136/ard.2004.034769. Epub 2005 May 18.

  PMID: 15901635 BACKGROUND

• Summers GD, Metsios GS, Stavropoulos-Kalinoglou A, Kitas GD. Rheumatoid cachexia and cardiovascular disease. Nat Rev Rheumatol. 2010 Aug;6(8):445-51. doi: 10.1038/nrrheum.2010.105. Epub 2010 Jul 20.

  PMID: 20647995 BACKGROUND

• Alaranta H, Hurri H, Heliovaara M, Soukka A, Harju R. Non-dynamometric trunk performance tests: reliability and normative data. Scand J Rehabil Med. 1994 Dec;26(4):211-5.

  PMID: 7878396 BACKGROUND

Related Links

• 9.Balsamo et al. BMC MusculoskeletalDisorders 2013, 14:263
• 2.Biolo G, Cederholm T, Muscaritoli M. Muscle contractile and metabolic dysfunction isacommonfeature ofsarcopenia of ang and chronic diseases: From sarcopenic obesity to sarcopenic obesity to cachexia. Clin Nutr. 2014; 33:737-748

MeSH Terms

Conditions

Rheumatic Diseases

Interventions

Blood Cell Count; Immunologic Tests

Condition Hierarchy (Ancestors)

Musculoskeletal Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Cell Count; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Hematologic Tests; Investigative Techniques; Cell Physiological Phenomena; Blood Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena; Immunologic Techniques

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Study Record Dates

• First Submitted: October 24, 2018
• First Posted: November 2, 2018
• Study Start: November 15, 2018
• Primary Completion: November 11, 2019
• Study Completion: February 2, 2020
• Last Updated: November 2, 2018

Record last verified: 2018-10